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Immunologic basis for adverse reactions to radiographic contrast media

Journal Article:

Abstract

The lymphocyte transformation test (LTT) was used to elucidate whether certain side effects induced by radiographic contrast media have an immunologic etiology. Groups studied were: 8 patients who had previously experienced adverse reactions in association with urography, 6 patients who underwent urography without notable side reactions, 17 occupationally exposed nurses, and 9 unexposed controls. The lymphocytes from 2 hypersensitive patients and from 11 nurses exhibited a positive proliferative response to amidotrizoate. Five nurses who had shown a positive response, had a previous history of hypersensitivity reactions when handling contrast media, whereas the remaining 6 were free of symptoms. Amidotrizoatespecific memory cells were absent in patients who underwent urography without signs of hypersensitivity and in 7/9 of unexposed control subjects. Lymphocytes from patients sensitive to amidotrizoate cross-reacted to structurally related ionic contrast media while nonionic contrast agents did not induce proliferation of the lymphocytes. Thus, ionic radiographic contrast agents have antigenic properties in man. Irradiated mixtures of radiographic contrast media and serum proteins were, in general, not effective in inducing an LTT response. (orig.).
Authors:
Stejskal, V; Nilsson, R; Grepe, A [1] 
  1. Astra Pharmaceuticals AB, Soedertaelje (Sweden). Lab. of Safety Assessment Stockholm Univ. (Sweden). Dept. of Genetic and Cellular Toxicology Stockholm Univ. (Sweden). Wallenberglaboratoriet Danderyds Sjukhus, Danderyd (Sweden). Radiologic Clinic
Publication Date:
Nov 01, 1990
Product Type:
Journal Article
Reference Number:
AIX-22-037535; EDB-91-066476
Resource Relation:
Journal Name: Acta Radiologica; (Sweden); Journal Volume: 31:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CONTRAST MEDIA; ALLERGY; SIDE EFFECTS; IMMUNOLOGY; BIOASSAY; BIOMEDICAL RADIOGRAPHY; LYMPHOCYTES; MAN; MEDICAL PERSONNEL; PATIENTS; SENSITIVITY; X-RAY RADIOGRAPHY; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DIAGNOSTIC TECHNIQUES; INDUSTRIAL RADIOGRAPHY; LEUKOCYTES; MAMMALS; MATERIALS; MEDICINE; NUCLEAR MEDICINE; PATHOLOGICAL CHANGES; PERSONNEL; PRIMATES; RADIOLOGY; SOMATIC CELLS; VERTEBRATES; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
5959439
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0284-1851; CODEN: ACRAE
Submitting Site:
DKN
Size:
Pages: 605-612
Announcement Date:

Journal Article:

Citation Formats

Stejskal, V, Nilsson, R, and Grepe, A. Immunologic basis for adverse reactions to radiographic contrast media. Denmark: N. p., 1990. Web.
Stejskal, V, Nilsson, R, & Grepe, A. Immunologic basis for adverse reactions to radiographic contrast media. Denmark.
Stejskal, V, Nilsson, R, and Grepe, A. 1990. "Immunologic basis for adverse reactions to radiographic contrast media." Denmark.
@misc{etde_5959439,
title = {Immunologic basis for adverse reactions to radiographic contrast media}
author = {Stejskal, V, Nilsson, R, and Grepe, A}
abstractNote = {The lymphocyte transformation test (LTT) was used to elucidate whether certain side effects induced by radiographic contrast media have an immunologic etiology. Groups studied were: 8 patients who had previously experienced adverse reactions in association with urography, 6 patients who underwent urography without notable side reactions, 17 occupationally exposed nurses, and 9 unexposed controls. The lymphocytes from 2 hypersensitive patients and from 11 nurses exhibited a positive proliferative response to amidotrizoate. Five nurses who had shown a positive response, had a previous history of hypersensitivity reactions when handling contrast media, whereas the remaining 6 were free of symptoms. Amidotrizoatespecific memory cells were absent in patients who underwent urography without signs of hypersensitivity and in 7/9 of unexposed control subjects. Lymphocytes from patients sensitive to amidotrizoate cross-reacted to structurally related ionic contrast media while nonionic contrast agents did not induce proliferation of the lymphocytes. Thus, ionic radiographic contrast agents have antigenic properties in man. Irradiated mixtures of radiographic contrast media and serum proteins were, in general, not effective in inducing an LTT response. (orig.).}
journal = {Acta Radiologica; (Sweden)}
volume = {31:6}
journal type = {AC}
place = {Denmark}
year = {1990}
month = {Nov}
}