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Regional in vivo binding of (/sup 3/H)N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors

Journal Article:

Abstract

Tail vein injections of (/sup 3/H)N-propylnorapomorphine ((/sup 3/H)NPA) in male mice resulted in a dose-related accumulation of radioactivity in the following brain regions: striatum (max), olfactory tubercle and cerebellum (min). The specific binding was saturable with increasing concentrations of the drug and stereospecifically displaced by (+)butaclamol. Dopamine agonists (apomorphine, NPA and bromocriptine) and antagonists (spiperone, haloperidol, (+)butaclamol and l-sulpiride) all caused dose-dependent prevention of (/sup 3/H)NPA binding. Mianserin, phenoxybenzamine and propranolol did not prevent the in vivo (/sup 3/H)NPA binding suggesting that (/sup 3/H)NPA binds specifically to dopamine receptors in the striatum and the olfactory tubercle of the mouse.
Authors:
Koehler, C; Fuxe, K; Ross, S B [1] 
  1. Astra Pharmaceuticals AB, Soedertaelje (Sweden)
Publication Date:
Jul 10, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-634742; EDB-82-004785
Resource Relation:
Journal Name: Eur. J. Pharmacol.; (Netherlands); Journal Volume: 72:4
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; RADIONUCLIDE KINETICS; MORPHINE; RECEPTORS; TISSUE DISTRIBUTION; LABELLING; MICE; TRITIUM; UPTAKE; ALKALOIDS; ANALGESICS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISTRIBUTION; DRUGS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NARCOTICS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; OPIUM; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
5952661
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJPHA
Submitting Site:
INIS
Size:
Pages: 397-402
Announcement Date:

Journal Article:

Citation Formats

Koehler, C, Fuxe, K, and Ross, S B. Regional in vivo binding of (/sup 3/H)N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors. Netherlands: N. p., 1981. Web.
Koehler, C, Fuxe, K, & Ross, S B. Regional in vivo binding of (/sup 3/H)N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors. Netherlands.
Koehler, C, Fuxe, K, and Ross, S B. 1981. "Regional in vivo binding of (/sup 3/H)N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors." Netherlands.
@misc{etde_5952661,
title = {Regional in vivo binding of (/sup 3/H)N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors}
author = {Koehler, C, Fuxe, K, and Ross, S B}
abstractNote = {Tail vein injections of (/sup 3/H)N-propylnorapomorphine ((/sup 3/H)NPA) in male mice resulted in a dose-related accumulation of radioactivity in the following brain regions: striatum (max), olfactory tubercle and cerebellum (min). The specific binding was saturable with increasing concentrations of the drug and stereospecifically displaced by (+)butaclamol. Dopamine agonists (apomorphine, NPA and bromocriptine) and antagonists (spiperone, haloperidol, (+)butaclamol and l-sulpiride) all caused dose-dependent prevention of (/sup 3/H)NPA binding. Mianserin, phenoxybenzamine and propranolol did not prevent the in vivo (/sup 3/H)NPA binding suggesting that (/sup 3/H)NPA binds specifically to dopamine receptors in the striatum and the olfactory tubercle of the mouse.}
journal = {Eur. J. Pharmacol.; (Netherlands)}
volume = {72:4}
journal type = {AC}
place = {Netherlands}
year = {1981}
month = {Jul}
}