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{sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits

Abstract

Radiation synovectomy is a noninvasive therapy that has been investigated as an alternative to surgical synovectomy. It is been successfully employed in the treatment of synovitis in rheumatoid arthrits and other inflammatory arthropathies. We developed the {sup 166}Ho-chitosan complex for possible use as a radiation synovectomy agent. Holmium is the more practical isotope based on its higher radioactivity and logner half-life. And isotope based on its higher radioactivity and logner half-life. And chitosan is ideal and suitable particles based on its soluble and biodegradable characteristics. So we investigated the biocompatibility of the {sup 166}Ho-chitosan complex to evaluated the suitability as a radiation synovectomy agent. In this study, we performed in vivo and in vitro stability test and biodistribution test. Our results indicate that {sup 166}Ho-chitosan may be an effective radiopharmaceutical for radiation synovectomy. (author). 30 refs., 7 tabs.
Authors:
Kim, Sug Jun; Lee, Soo Yong; Jeon, Dae Geun; Seok, Lee Jong [1] 
  1. Korea Cancer Center Hospital, Seoul (Korea, Republic of)
Publication Date:
Jan 01, 1997
Product Type:
Technical Report
Report Number:
KAERI/RR-1652/96
Reference Number:
SCA: 400703; 550604; PA: AIX-29:000805; EDB-98:052461; SN: 98001898813
Resource Relation:
Other Information: PBD: Jan 1997
Subject:
40 CHEMISTRY; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; ALKALINE HYDROLYSIS; BETA DECAY RADIOISOTOPES; BIOASSAY; BONE JOINTS; HOLMIUM COMPOUNDS; HOLMIUM 166; IN VITRO; IN VIVO; NEUTRON REACTIONS; RABBITS; RADIATION CURING; RADIOPHARMACEUTICALS
OSTI ID:
595249
Research Organizations:
Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Other: ON: DE98607770; TRN: KR9700234000805
Availability:
INIS; OSTI as DE98607770
Submitting Site:
KRN
Size:
38 p.
Announcement Date:

Citation Formats

Kim, Sug Jun, Lee, Soo Yong, Jeon, Dae Geun, and Seok, Lee Jong. {sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits. Korea, Republic of: N. p., 1997. Web.
Kim, Sug Jun, Lee, Soo Yong, Jeon, Dae Geun, & Seok, Lee Jong. {sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits. Korea, Republic of.
Kim, Sug Jun, Lee, Soo Yong, Jeon, Dae Geun, and Seok, Lee Jong. 1997. "{sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits." Korea, Republic of.
@misc{etde_595249,
title = {{sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits}
author = {Kim, Sug Jun, Lee, Soo Yong, Jeon, Dae Geun, and Seok, Lee Jong}
abstractNote = {Radiation synovectomy is a noninvasive therapy that has been investigated as an alternative to surgical synovectomy. It is been successfully employed in the treatment of synovitis in rheumatoid arthrits and other inflammatory arthropathies. We developed the {sup 166}Ho-chitosan complex for possible use as a radiation synovectomy agent. Holmium is the more practical isotope based on its higher radioactivity and logner half-life. And isotope based on its higher radioactivity and logner half-life. And chitosan is ideal and suitable particles based on its soluble and biodegradable characteristics. So we investigated the biocompatibility of the {sup 166}Ho-chitosan complex to evaluated the suitability as a radiation synovectomy agent. In this study, we performed in vivo and in vitro stability test and biodistribution test. Our results indicate that {sup 166}Ho-chitosan may be an effective radiopharmaceutical for radiation synovectomy. (author). 30 refs., 7 tabs.}
place = {Korea, Republic of}
year = {1997}
month = {Jan}
}