Abstract
The binding of (1,2,6,7-/sup 3/H)-corticosterone was studied in brain cytosol from normal and streptozotocin-diabetic male rats. The experiments were performed under conditions of incubation time (4h), temperature (0-4/sup 0/C), time after adrenalectomy (6 days) and corticosterone concentrations (1.2 x 10/sup -8/ and 1.15 x 10/sup -9/M) previously established for determining binding activity in the brain of normal rats. The binding of (/sup 3/H)-corticosterone was found invariably lower in cytosol of the brain from diabetic rats, studied under three different conditions in non-adrenalectomized animals, in adrenalectomized using a non-saturating corticosterone concentration, and in adrenalectomized plus a saturating steroid concentration. These results support previous contentions that the diminished sensitivity to the negative feedback for steroids which is present in diabetics, may be related to a reduction in binding capacity for corticoids in the central nervous system.
Fridman, O;
Foglia, V G;
de Nicola, A F
[1]
- Instituto de Biologia y Medicina Experimental, Buenos Aires (Argentina). Lab. de Esteroides
Citation Formats
Fridman, O, Foglia, V G, and de Nicola, A F.
Reduction in (/sup 3/H)-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats.
United Kingdom: N. p.,
1978.
Web.
doi:10.1016/0022-4731(78)90171-1.
Fridman, O, Foglia, V G, & de Nicola, A F.
Reduction in (/sup 3/H)-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats.
United Kingdom.
https://doi.org/10.1016/0022-4731(78)90171-1
Fridman, O, Foglia, V G, and de Nicola, A F.
1978.
"Reduction in (/sup 3/H)-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats."
United Kingdom.
https://doi.org/10.1016/0022-4731(78)90171-1.
@misc{etde_5935052,
title = {Reduction in (/sup 3/H)-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats}
author = {Fridman, O, Foglia, V G, and de Nicola, A F}
abstractNote = {The binding of (1,2,6,7-/sup 3/H)-corticosterone was studied in brain cytosol from normal and streptozotocin-diabetic male rats. The experiments were performed under conditions of incubation time (4h), temperature (0-4/sup 0/C), time after adrenalectomy (6 days) and corticosterone concentrations (1.2 x 10/sup -8/ and 1.15 x 10/sup -9/M) previously established for determining binding activity in the brain of normal rats. The binding of (/sup 3/H)-corticosterone was found invariably lower in cytosol of the brain from diabetic rats, studied under three different conditions in non-adrenalectomized animals, in adrenalectomized using a non-saturating corticosterone concentration, and in adrenalectomized plus a saturating steroid concentration. These results support previous contentions that the diminished sensitivity to the negative feedback for steroids which is present in diabetics, may be related to a reduction in binding capacity for corticoids in the central nervous system.}
doi = {10.1016/0022-4731(78)90171-1}
journal = []
volume = {9:7}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jul}
}
title = {Reduction in (/sup 3/H)-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats}
author = {Fridman, O, Foglia, V G, and de Nicola, A F}
abstractNote = {The binding of (1,2,6,7-/sup 3/H)-corticosterone was studied in brain cytosol from normal and streptozotocin-diabetic male rats. The experiments were performed under conditions of incubation time (4h), temperature (0-4/sup 0/C), time after adrenalectomy (6 days) and corticosterone concentrations (1.2 x 10/sup -8/ and 1.15 x 10/sup -9/M) previously established for determining binding activity in the brain of normal rats. The binding of (/sup 3/H)-corticosterone was found invariably lower in cytosol of the brain from diabetic rats, studied under three different conditions in non-adrenalectomized animals, in adrenalectomized using a non-saturating corticosterone concentration, and in adrenalectomized plus a saturating steroid concentration. These results support previous contentions that the diminished sensitivity to the negative feedback for steroids which is present in diabetics, may be related to a reduction in binding capacity for corticoids in the central nervous system.}
doi = {10.1016/0022-4731(78)90171-1}
journal = []
volume = {9:7}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jul}
}