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Cytogenetic patterns in acute nonlymphocytic leukemia

Journal Article:

Abstract

Analysis of chromosomal banding patterns in acute nonlymphocytic leukemia (ANLL) reveals that approximately 50% of patients have an abnormal karyotype. Although there is substantial variability, certain nonrandom abnormalities occur, e.g., +8, -7, and the 8;21 translocation (often accompanied by loss of an X or Y chromosome). The 15;17 translocation appears to be highly specific for acute promyelocytic leukemia. These abnormalities usually are not seen in remission, but reappear in relapse, sometimes exhibiting further clonal evolution; a +8 is the most frequently observed evolutionary change. Patients with ANLL following treatment of a malignant lymphoma tend to have hypodiploid modal numbers and frequently show loss of a chromosome No. 5 or No. 7.
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
EDB-79-113353
Resource Relation:
Journal Name: Virchows Arch., B; (Germany, Federal Republic of); Journal Volume: 29
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LEUKEMIA; CHROMOSOMAL ABERRATIONS; BONE MARROW CELLS; CHROMOSOME LOSSES; CORRELATIONS; KARYOTYPE; MAN; ANIMAL CELLS; ANIMALS; CONNECTIVE TISSUE CELLS; DISEASES; HEMIC DISEASES; MAMMALS; MUTATIONS; NEOPLASMS; PRIMATES; SOMATIC CELLS; VERTEBRATES; 550600* - Medicine
OSTI ID:
5934167
Research Organizations:
Univ. of Chicago, IL
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: VAAZA
Submitting Site:
TIC
Size:
Pages: 65-72
Announcement Date:

Journal Article:

Citation Formats

Testa, J R, and Rowley, J D. Cytogenetic patterns in acute nonlymphocytic leukemia. Germany: N. p., 1978. Web.
Testa, J R, & Rowley, J D. Cytogenetic patterns in acute nonlymphocytic leukemia. Germany.
Testa, J R, and Rowley, J D. 1978. "Cytogenetic patterns in acute nonlymphocytic leukemia." Germany.
@misc{etde_5934167,
title = {Cytogenetic patterns in acute nonlymphocytic leukemia}
author = {Testa, J R, and Rowley, J D}
abstractNote = {Analysis of chromosomal banding patterns in acute nonlymphocytic leukemia (ANLL) reveals that approximately 50% of patients have an abnormal karyotype. Although there is substantial variability, certain nonrandom abnormalities occur, e.g., +8, -7, and the 8;21 translocation (often accompanied by loss of an X or Y chromosome). The 15;17 translocation appears to be highly specific for acute promyelocytic leukemia. These abnormalities usually are not seen in remission, but reappear in relapse, sometimes exhibiting further clonal evolution; a +8 is the most frequently observed evolutionary change. Patients with ANLL following treatment of a malignant lymphoma tend to have hypodiploid modal numbers and frequently show loss of a chromosome No. 5 or No. 7.}
journal = {Virchows Arch., B; (Germany, Federal Republic of)}
volume = {29}
journal type = {AC}
place = {Germany}
year = {1978}
month = {Jan}
}