Abstract
Eighteen patients with atrial fibrillation were given digoxin 0.13 mg twice daily for 3 weeks and ..beta..-methyldigoxin 0.10 mg twice daily for another 3 weeks. At the end of each 3 week period an exercise test was performed and the effects on the heart rate of the two drugs were compared. No difference in heart rate was obtained at rest, wheareas the heart rate after 6 min of exercise was higher during treatment with digoxin (131 beats/min) than when the patients were taking ..beta..-methyldigoxin (124 beats/min). There were no significant differences between digoxin and ..beta..-methyldigoxin in their effects on the ECT (R-R intervals, T-wave, Q-T duration). The plasma concentrations of the two glycosides were determined by radioimmunoassay and by /sup 86/Rb-uptake inhibition assay. Comparable plasma concentration values (1.0 ng/ml for digoxin, 1.1 ng/ml for ..beta..-methyldigoxin, mean values) were obtained by radioimmunoassay, but the /sup 86/Rb-technique gave significantly higher values (mean 1.5 ng/ml) for ..beta..-methyldigoxin. It is concluded that ..beta..-methyldigoxin is equal to digoxin for producing slowing of the heart rate in patients with atrial fibrillation.
Andersson, K E;
Johansson, B W;
Ledermann, H;
von Schenck, H;
Thorell, J I;
[1]
Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab.;
Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry)
- Lund Univ. (Sweden). Clinical Pharmacological Lab.
Citation Formats
Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry).
Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation.
Germany: N. p.,
1977.
Web.
Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., & Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry).
Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation.
Germany.
Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry).
1977.
"Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation."
Germany.
@misc{etde_5933694,
title = {Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation}
author = {Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry)}
abstractNote = {Eighteen patients with atrial fibrillation were given digoxin 0.13 mg twice daily for 3 weeks and ..beta..-methyldigoxin 0.10 mg twice daily for another 3 weeks. At the end of each 3 week period an exercise test was performed and the effects on the heart rate of the two drugs were compared. No difference in heart rate was obtained at rest, wheareas the heart rate after 6 min of exercise was higher during treatment with digoxin (131 beats/min) than when the patients were taking ..beta..-methyldigoxin (124 beats/min). There were no significant differences between digoxin and ..beta..-methyldigoxin in their effects on the ECT (R-R intervals, T-wave, Q-T duration). The plasma concentrations of the two glycosides were determined by radioimmunoassay and by /sup 86/Rb-uptake inhibition assay. Comparable plasma concentration values (1.0 ng/ml for digoxin, 1.1 ng/ml for ..beta..-methyldigoxin, mean values) were obtained by radioimmunoassay, but the /sup 86/Rb-technique gave significantly higher values (mean 1.5 ng/ml) for ..beta..-methyldigoxin. It is concluded that ..beta..-methyldigoxin is equal to digoxin for producing slowing of the heart rate in patients with atrial fibrillation.}
journal = {Eur. J. Clin. Invest.; (Germany, Federal Republic of)}
volume = {7:1}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Feb}
}
title = {Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation}
author = {Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry)}
abstractNote = {Eighteen patients with atrial fibrillation were given digoxin 0.13 mg twice daily for 3 weeks and ..beta..-methyldigoxin 0.10 mg twice daily for another 3 weeks. At the end of each 3 week period an exercise test was performed and the effects on the heart rate of the two drugs were compared. No difference in heart rate was obtained at rest, wheareas the heart rate after 6 min of exercise was higher during treatment with digoxin (131 beats/min) than when the patients were taking ..beta..-methyldigoxin (124 beats/min). There were no significant differences between digoxin and ..beta..-methyldigoxin in their effects on the ECT (R-R intervals, T-wave, Q-T duration). The plasma concentrations of the two glycosides were determined by radioimmunoassay and by /sup 86/Rb-uptake inhibition assay. Comparable plasma concentration values (1.0 ng/ml for digoxin, 1.1 ng/ml for ..beta..-methyldigoxin, mean values) were obtained by radioimmunoassay, but the /sup 86/Rb-technique gave significantly higher values (mean 1.5 ng/ml) for ..beta..-methyldigoxin. It is concluded that ..beta..-methyldigoxin is equal to digoxin for producing slowing of the heart rate in patients with atrial fibrillation.}
journal = {Eur. J. Clin. Invest.; (Germany, Federal Republic of)}
volume = {7:1}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Feb}
}