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Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation

Journal Article:

Abstract

Eighteen patients with atrial fibrillation were given digoxin 0.13 mg twice daily for 3 weeks and ..beta..-methyldigoxin 0.10 mg twice daily for another 3 weeks. At the end of each 3 week period an exercise test was performed and the effects on the heart rate of the two drugs were compared. No difference in heart rate was obtained at rest, wheareas the heart rate after 6 min of exercise was higher during treatment with digoxin (131 beats/min) than when the patients were taking ..beta..-methyldigoxin (124 beats/min). There were no significant differences between digoxin and ..beta..-methyldigoxin in their effects on the ECT (R-R intervals, T-wave, Q-T duration). The plasma concentrations of the two glycosides were determined by radioimmunoassay and by /sup 86/Rb-uptake inhibition assay. Comparable plasma concentration values (1.0 ng/ml for digoxin, 1.1 ng/ml for ..beta..-methyldigoxin, mean values) were obtained by radioimmunoassay, but the /sup 86/Rb-technique gave significantly higher values (mean 1.5 ng/ml) for ..beta..-methyldigoxin. It is concluded that ..beta..-methyldigoxin is equal to digoxin for producing slowing of the heart rate in patients with atrial fibrillation.
Publication Date:
Feb 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-10-421023; EDB-79-113429
Resource Relation:
Journal Name: Eur. J. Clin. Invest.; (Germany, Federal Republic of); Journal Volume: 7:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CARDIOVASCULAR DISEASES; THERAPY; DIGITALIS GLYCOSIDES; RADIOASSAY; RADIOIMMUNOASSAY; HEART; DYNAMIC FUNCTION STUDIES; ANTIGEN-ANTIBODY REACTIONS; BLOOD PLASMA; COMPARATIVE EVALUATIONS; EXERCISE; INHIBITION; PATIENTS; RUBIDIUM 86; UPTAKE; ALKALI METAL ISOTOPES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; GLYCOSIDES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RUBIDIUM ISOTOPES; STEROIDS; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550901 - Pathology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques
OSTI ID:
5933694
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJCIB
Submitting Site:
INIS
Size:
Pages: 3-6
Announcement Date:
Feb 01, 1979

Journal Article:

Citation Formats

Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry). Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation. Germany: N. p., 1977. Web.
Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., & Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry). Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation. Germany.
Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry). 1977. "Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation." Germany.
@misc{etde_5933694,
title = {Effects of digoxin and. beta. -methyldigoxin on the heart rate of decompensated patients with atrial fibrillation}
author = {Andersson, K E, Johansson, B W, Ledermann, H, von Schenck, H, Thorell, J I, Allmaenna Sjukhuset, Malmoe (Sweden). Heat Lab., and Allmaenna Sjukhuset, Malmoe (Sweden). Dept. of Clinical Chemistry)}
abstractNote = {Eighteen patients with atrial fibrillation were given digoxin 0.13 mg twice daily for 3 weeks and ..beta..-methyldigoxin 0.10 mg twice daily for another 3 weeks. At the end of each 3 week period an exercise test was performed and the effects on the heart rate of the two drugs were compared. No difference in heart rate was obtained at rest, wheareas the heart rate after 6 min of exercise was higher during treatment with digoxin (131 beats/min) than when the patients were taking ..beta..-methyldigoxin (124 beats/min). There were no significant differences between digoxin and ..beta..-methyldigoxin in their effects on the ECT (R-R intervals, T-wave, Q-T duration). The plasma concentrations of the two glycosides were determined by radioimmunoassay and by /sup 86/Rb-uptake inhibition assay. Comparable plasma concentration values (1.0 ng/ml for digoxin, 1.1 ng/ml for ..beta..-methyldigoxin, mean values) were obtained by radioimmunoassay, but the /sup 86/Rb-technique gave significantly higher values (mean 1.5 ng/ml) for ..beta..-methyldigoxin. It is concluded that ..beta..-methyldigoxin is equal to digoxin for producing slowing of the heart rate in patients with atrial fibrillation.}
journal = {Eur. J. Clin. Invest.; (Germany, Federal Republic of)}
volume = {7:1}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Feb}
}