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Acute myeloid leukemia induction in CBA/H mice by irradiation with fission neutrons as a function of exposure rate

Abstract

Radiation-induced acute myeloid leukemia (AML) in male CBA/H mice was used as a model for investigation of the effect of reduced fast fission neutron exposure rates on radiation-induced carcinogenesis. Groups of about 90 male CBA/H mice were irradiated or sham-irradiated at the age of 15-20 weeks. The animals were exposed to 400 mGy fast fission neutrons at exposure rates of 2, 10 or 100 mGy/min. The investigation clearly showed that reducing the exposure rate of high-LET fast fission neutrons had no influence on the incidence of AML or on the survival of the irradiated mice. In contrast, a higher incidence of lymphosarcomas was observed in mice irradiated with higher exposure rates. (orig./MG).
Authors:
Huiskamp, R [1] 
  1. Stichting Energieonderzoek Centrum Nederland, Petten (Netherlands). Radiobiology and Radio-Ecology Unit
Publication Date:
Jun 01, 1991
Product Type:
Journal Article
Reference Number:
DEN-91-004009; EDB-91-078237
Resource Relation:
Journal Name: Radiation and Environmental Biophysics; (Germany, F.R.); Journal Volume: 30:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FISSION NEUTRONS; LEUKEMOGENESIS; LET; BIOLOGICAL MODELS; EXTERNAL IRRADIATION; LYMPHOSARCOMAS; MICE; MYELOID LEUKEMIA; NEUTRON BEAMS; RADIATION HAZARDS; SURVIVAL CURVES; ANIMALS; BARYONS; BEAMS; CARCINOGENESIS; DISEASES; ELEMENTARY PARTICLES; ENERGY TRANSFER; FERMIONS; HADRONS; HAZARDS; HEALTH HAZARDS; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; IRRADIATION; LEUKEMIA; LYMPHOMAS; MAMMALS; NEOPLASMS; NEUTRONS; NUCLEON BEAMS; NUCLEONS; PARTICLE BEAMS; PATHOGENESIS; RODENTS; SARCOMAS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5916016
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0301-634X; CODEN: REBPA
Submitting Site:
DEN
Size:
Pages: 213-215
Announcement Date:

Citation Formats

Huiskamp, R. Acute myeloid leukemia induction in CBA/H mice by irradiation with fission neutrons as a function of exposure rate. Germany: N. p., 1991. Web. doi:10.1007/BF01226622.
Huiskamp, R. Acute myeloid leukemia induction in CBA/H mice by irradiation with fission neutrons as a function of exposure rate. Germany. doi:10.1007/BF01226622.
Huiskamp, R. 1991. "Acute myeloid leukemia induction in CBA/H mice by irradiation with fission neutrons as a function of exposure rate." Germany. doi:10.1007/BF01226622. https://www.osti.gov/servlets/purl/10.1007/BF01226622.
@misc{etde_5916016,
title = {Acute myeloid leukemia induction in CBA/H mice by irradiation with fission neutrons as a function of exposure rate}
author = {Huiskamp, R}
abstractNote = {Radiation-induced acute myeloid leukemia (AML) in male CBA/H mice was used as a model for investigation of the effect of reduced fast fission neutron exposure rates on radiation-induced carcinogenesis. Groups of about 90 male CBA/H mice were irradiated or sham-irradiated at the age of 15-20 weeks. The animals were exposed to 400 mGy fast fission neutrons at exposure rates of 2, 10 or 100 mGy/min. The investigation clearly showed that reducing the exposure rate of high-LET fast fission neutrons had no influence on the incidence of AML or on the survival of the irradiated mice. In contrast, a higher incidence of lymphosarcomas was observed in mice irradiated with higher exposure rates. (orig./MG).}
doi = {10.1007/BF01226622}
journal = {Radiation and Environmental Biophysics; (Germany, F.R.)}
volume = {30:3}
journal type = {AC}
place = {Germany}
year = {1991}
month = {Jun}
}