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Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice

Journal Article:

Abstract

The radiogenetoxicological effects on the adult testis and the metabolic difference of tritiated thymidine between the testis of young and adult BALB/C mice were studied. When 0.037 MBq/g.b.w. of tritiated thymidine was given i.v. to mice, the initial burden of tritium in the adult was larger than that of tritium in the young. But the retention of tritium in testis of the young gradually become larger than that of tritium in the adult with the passing time. Tritiated thymidine which was incorporated into DNA of the male germ cell nuclei damaged the genetic materials and caused the rising of the rates of the dominant lethal and the dominant mutation which produced skeletal abnomalities in the offspring. The relationship between the dominant lethal mutation index (Y) and the injected activity of tritiated thymidine (I, MBq/g.b.w.) is described by Y = 74.13 + 80.20 I (r = 0.95). The relationship between the incidence of the dominant skeletal mutation in the offspring (B) and the injected activity is B = 0.16 + 0.079 I ( r = 0.85).
Publication Date:
Apr 01, 1990
Product Type:
Journal Article
Reference Number:
AIX-22-043257; EDB-91-078277
Resource Relation:
Journal Name: Acta Academiae Medicinae Suzhou (Suzhou Yixueyuan Xuebao); (China); Journal Volume: 10:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LABELLED COMPOUNDS; METABOLISM; TESTES; RADIATION INJURIES; TRITIUM; BIOLOGICAL HALF-LIFE; GENETIC RADIATION EFFECTS; GERM CELLS; LABELLING; MICE; THYMIDINE; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; GENETIC EFFECTS; GONADS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; INJURIES; ISOTOPES; LIGHT NUCLEI; MALE GENITALS; MAMMALS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIATION EFFECTS; RADIOISOTOPES; RIBOSIDES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells
OSTI ID:
5915766
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: CODEN: SYIXE
Submitting Site:
INIS
Size:
Pages: 98-101
Announcement Date:
Jun 15, 1991

Journal Article:

Citation Formats

Mingyue, Lun, and Shoupeng, Zhu. Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice. China: N. p., 1990. Web.
Mingyue, Lun, & Shoupeng, Zhu. Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice. China.
Mingyue, Lun, and Shoupeng, Zhu. 1990. "Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice." China.
@misc{etde_5915766,
title = {Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice}
author = {Mingyue, Lun, and Shoupeng, Zhu}
abstractNote = {The radiogenetoxicological effects on the adult testis and the metabolic difference of tritiated thymidine between the testis of young and adult BALB/C mice were studied. When 0.037 MBq/g.b.w. of tritiated thymidine was given i.v. to mice, the initial burden of tritium in the adult was larger than that of tritium in the young. But the retention of tritium in testis of the young gradually become larger than that of tritium in the adult with the passing time. Tritiated thymidine which was incorporated into DNA of the male germ cell nuclei damaged the genetic materials and caused the rising of the rates of the dominant lethal and the dominant mutation which produced skeletal abnomalities in the offspring. The relationship between the dominant lethal mutation index (Y) and the injected activity of tritiated thymidine (I, MBq/g.b.w.) is described by Y = 74.13 + 80.20 I (r = 0.95). The relationship between the incidence of the dominant skeletal mutation in the offspring (B) and the injected activity is B = 0.16 + 0.079 I ( r = 0.85).}
journal = {Acta Academiae Medicinae Suzhou (Suzhou Yixueyuan Xuebao); (China)}
volume = {10:2}
journal type = {AC}
place = {China}
year = {1990}
month = {Apr}
}