Abstract
The peripheral blood changes in 44 patients who died of either acute leukemia or chronic granulocytic leukemia were evaluated during the preleukemic phase of their clinical illnesses at the time of routine health examination. The most striking finding was the presence of increased numbers of atypical and abnormal lymphocytes in the peripheral blood for periods of 3 to 4 years prior to establishment of the clinical diagnosis of both acute and chronic leukemia. Moderate leukocytosis with left-shifted myeloid cells and basophilia preceded the diagnosis of chronic granulocytic leukemia by 1 or 2 years. Basophilia did not occur in the absence of leukocytosis. The lymphocyte changes suggest the possibility that the host response to underlying clones of leukemic cells may exist for several years prior to the emergence of clinical leukemia. None of the preleukemic hematologic changes which previously have been defined in the preleukemic syndrome for acute leukemia was observed in any of the patients.
Citation Formats
Hoshino, T, Finch, S C, Lamphere, J P, and Ishimaru, T.
Peripheral blood changes preceding the development of leukemia in atomic bomb survivors: Hiroshima and Nagasaki, 1947--1962.
Japan: N. p.,
1975.
Web.
Hoshino, T, Finch, S C, Lamphere, J P, & Ishimaru, T.
Peripheral blood changes preceding the development of leukemia in atomic bomb survivors: Hiroshima and Nagasaki, 1947--1962.
Japan.
Hoshino, T, Finch, S C, Lamphere, J P, and Ishimaru, T.
1975.
"Peripheral blood changes preceding the development of leukemia in atomic bomb survivors: Hiroshima and Nagasaki, 1947--1962."
Japan.
@misc{etde_5913953,
title = {Peripheral blood changes preceding the development of leukemia in atomic bomb survivors: Hiroshima and Nagasaki, 1947--1962}
author = {Hoshino, T, Finch, S C, Lamphere, J P, and Ishimaru, T}
abstractNote = {The peripheral blood changes in 44 patients who died of either acute leukemia or chronic granulocytic leukemia were evaluated during the preleukemic phase of their clinical illnesses at the time of routine health examination. The most striking finding was the presence of increased numbers of atypical and abnormal lymphocytes in the peripheral blood for periods of 3 to 4 years prior to establishment of the clinical diagnosis of both acute and chronic leukemia. Moderate leukocytosis with left-shifted myeloid cells and basophilia preceded the diagnosis of chronic granulocytic leukemia by 1 or 2 years. Basophilia did not occur in the absence of leukocytosis. The lymphocyte changes suggest the possibility that the host response to underlying clones of leukemic cells may exist for several years prior to the emergence of clinical leukemia. None of the preleukemic hematologic changes which previously have been defined in the preleukemic syndrome for acute leukemia was observed in any of the patients.}
place = {Japan}
year = {1975}
month = {Jan}
}
title = {Peripheral blood changes preceding the development of leukemia in atomic bomb survivors: Hiroshima and Nagasaki, 1947--1962}
author = {Hoshino, T, Finch, S C, Lamphere, J P, and Ishimaru, T}
abstractNote = {The peripheral blood changes in 44 patients who died of either acute leukemia or chronic granulocytic leukemia were evaluated during the preleukemic phase of their clinical illnesses at the time of routine health examination. The most striking finding was the presence of increased numbers of atypical and abnormal lymphocytes in the peripheral blood for periods of 3 to 4 years prior to establishment of the clinical diagnosis of both acute and chronic leukemia. Moderate leukocytosis with left-shifted myeloid cells and basophilia preceded the diagnosis of chronic granulocytic leukemia by 1 or 2 years. Basophilia did not occur in the absence of leukocytosis. The lymphocyte changes suggest the possibility that the host response to underlying clones of leukemic cells may exist for several years prior to the emergence of clinical leukemia. None of the preleukemic hematologic changes which previously have been defined in the preleukemic syndrome for acute leukemia was observed in any of the patients.}
place = {Japan}
year = {1975}
month = {Jan}
}