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Possible error-prone repair of neoplastic transformation induced by fission-spectrum neutrons

Journal Article:

Abstract

An examination was made of the effect of fission-spectrum neutrons from the JANUS reactor at Argonne National Laboratory, delivered either as acute or protracted irradiation, on the incidence of neoplastic transformation in the C3H 10T1/2 mouse embryo cell line. Acute exposures were delivered at 10-38 cGy min/sup -1/, protracted exposures at 0.086 or 0.43 cGy min/sup -1/. The total doses for both ranged from 2.4 to 350 cGy. In the low dose region (2.4-80 cGy), there was a large enhancement in transformation frequency when the neutrons were delivered at the low dose rates compared with the high dose rates, but the survival of the cells was not significantly different between the two exposures conditions. Analysis of the intial parts of the curves shows that the regression line for protracted doses is about 9 times steeper than that for single acute exposures. Finally, the possibility is discussed that an ''error-prone'' repair process may be causing the enhanced transformation frequency by protracted neutron exposures.
Publication Date:
Jan 01, 1948
Product Type:
Journal Article
Reference Number:
ERA-10-019219; EDB-85-058408
Resource Relation:
Journal Name: Br. J. Cancer; (United Kingdom); Journal Volume: 49
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EMBRYONIC CELLS; BIOLOGICAL RADIATION EFFECTS; ONCOGENIC TRANSFORMATIONS; RADIOINDUCTION; ACUTE IRRADIATION; BIOLOGICAL REPAIR; CELL CULTURES; CELL KILLING; CHRONIC IRRADIATION; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; FISSION NEUTRONS; JANUS REACTOR; LOW DOSE IRRADIATION; MICE; NEOPLASMS; SURVIVAL CURVES; ACUTE EXPOSURE; ANIMAL CELLS; ANIMALS; BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; CHRONIC EXPOSURE; DISEASES; ELEMENTARY PARTICLES; ENRICHED URANIUM REACTORS; FERMIONS; HADRONS; IRRADIATION; MAMMALS; NEUTRONS; NUCLEONS; RADIATION EFFECTS; REACTORS; RECOVERY; REPAIR; RESEARCH AND TEST REACTORS; RESEARCH REACTORS; RODENTS; TANK TYPE REACTORS; THERMAL REACTORS; VERTEBRATES; WATER COOLED REACTORS; WATER MODERATED REACTORS; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5909939
Research Organizations:
Argonne National Lab., IL
Country of Origin:
United Kingdom
Language:
English
Contract Number:
W-31-109-ENG-38
Other Identifying Numbers:
Journal ID: CODEN: BJCAA
Submitting Site:
HEDB
Size:
Pages: 97-101
Announcement Date:

Journal Article:

Citation Formats

Hill, C K, Han, A, and Elkind, M M. Possible error-prone repair of neoplastic transformation induced by fission-spectrum neutrons. United Kingdom: N. p., 1948. Web.
Hill, C K, Han, A, & Elkind, M M. Possible error-prone repair of neoplastic transformation induced by fission-spectrum neutrons. United Kingdom.
Hill, C K, Han, A, and Elkind, M M. 1948. "Possible error-prone repair of neoplastic transformation induced by fission-spectrum neutrons." United Kingdom.
@misc{etde_5909939,
title = {Possible error-prone repair of neoplastic transformation induced by fission-spectrum neutrons}
author = {Hill, C K, Han, A, and Elkind, M M}
abstractNote = {An examination was made of the effect of fission-spectrum neutrons from the JANUS reactor at Argonne National Laboratory, delivered either as acute or protracted irradiation, on the incidence of neoplastic transformation in the C3H 10T1/2 mouse embryo cell line. Acute exposures were delivered at 10-38 cGy min/sup -1/, protracted exposures at 0.086 or 0.43 cGy min/sup -1/. The total doses for both ranged from 2.4 to 350 cGy. In the low dose region (2.4-80 cGy), there was a large enhancement in transformation frequency when the neutrons were delivered at the low dose rates compared with the high dose rates, but the survival of the cells was not significantly different between the two exposures conditions. Analysis of the intial parts of the curves shows that the regression line for protracted doses is about 9 times steeper than that for single acute exposures. Finally, the possibility is discussed that an ''error-prone'' repair process may be causing the enhanced transformation frequency by protracted neutron exposures.}
journal = {Br. J. Cancer; (United Kingdom)}
volume = {49}
journal type = {AC}
place = {United Kingdom}
year = {1948}
month = {Jan}
}