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Pathophysiological studies of experimental brain edema and cerebral ischemia using MRI/S

Journal Article:

Abstract

Pathophysiological changes in experimental brain edema and cerebral ischemia were examined by the in vivo /sup 1/H- and /sup 31/P-NMR method. Two types of experimental brain edema were induced in rats by cold injury and by triethyltin (TET) intoxication. Experimental cerebral ischemia was induced in rats by the four-vessel occlusion method. During the course of these pathological conditions, the /sup 1/H-MRIs and /sup 31/P-NMR spectra were measured sequentially with a single NMR spectrometer (4.8 tesla, 9 cm bore magnet). In the cold-injury edema, high-intensity lesions were detected in the gray and white matters of the injured hemisphere by means of SE images with a long Te 3 hours after the injury. The intensity reached its maximum 16 to 24 hours after the injury, and then returned to normal 7 days later. These high-intensity lesions indicated an increase in the T2 value in the edematous tissue. There were no changes in the /sup 31/P-NMR spectra during the course of edema formation and absorption. In the TET-induced edema, high-intensity lesions were also detected in the bilateral white matter by means of SE images with a long Te from the 3rd day up to the 7th day during the injection of TET. These  More>>
Publication Date:
Feb 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-87-059624; EDB-87-172498
Resource Relation:
Journal Name: CT Kenkyu; (Japan); Journal Volume: 9:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; NUCLEAR MAGNETIC RESONANCE; EDEMA; DIAGNOSIS; ISCHEMIA; BIOCHEMISTRY; HYDROGEN 1; NMR IMAGING; NMR SPECTRA; PHOSPHORUS 31; RATS; TIN COMPOUNDS; ANIMALS; BODY; BRAIN; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; CHEMISTRY; DIAGNOSTIC TECHNIQUES; DISEASES; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; PHOSPHORUS ISOTOPES; RESONANCE; RODENTS; SPECTRA; STABLE ISOTOPES; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 550600* - Medicine
OSTI ID:
5903003
Research Organizations:
Kyoto Prefectural Univ. of Medicine, Japan
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: CTKED
Submitting Site:
JPN
Size:
Pages: 27-33
Announcement Date:

Journal Article:

Citation Formats

Naruse, S, Higuchi, T, Horikawa, Y, Tanaka, C, and Hirakawa, K. Pathophysiological studies of experimental brain edema and cerebral ischemia using MRI/S. Japan: N. p., 1987. Web.
Naruse, S, Higuchi, T, Horikawa, Y, Tanaka, C, & Hirakawa, K. Pathophysiological studies of experimental brain edema and cerebral ischemia using MRI/S. Japan.
Naruse, S, Higuchi, T, Horikawa, Y, Tanaka, C, and Hirakawa, K. 1987. "Pathophysiological studies of experimental brain edema and cerebral ischemia using MRI/S." Japan.
@misc{etde_5903003,
title = {Pathophysiological studies of experimental brain edema and cerebral ischemia using MRI/S}
author = {Naruse, S, Higuchi, T, Horikawa, Y, Tanaka, C, and Hirakawa, K}
abstractNote = {Pathophysiological changes in experimental brain edema and cerebral ischemia were examined by the in vivo /sup 1/H- and /sup 31/P-NMR method. Two types of experimental brain edema were induced in rats by cold injury and by triethyltin (TET) intoxication. Experimental cerebral ischemia was induced in rats by the four-vessel occlusion method. During the course of these pathological conditions, the /sup 1/H-MRIs and /sup 31/P-NMR spectra were measured sequentially with a single NMR spectrometer (4.8 tesla, 9 cm bore magnet). In the cold-injury edema, high-intensity lesions were detected in the gray and white matters of the injured hemisphere by means of SE images with a long Te 3 hours after the injury. The intensity reached its maximum 16 to 24 hours after the injury, and then returned to normal 7 days later. These high-intensity lesions indicated an increase in the T2 value in the edematous tissue. There were no changes in the /sup 31/P-NMR spectra during the course of edema formation and absorption. In the TET-induced edema, high-intensity lesions were also detected in the bilateral white matter by means of SE images with a long Te from the 3rd day up to the 7th day during the injection of TET. These high-intensity lesions subsided 42 days after the discontinuance of injecting TET. There were no changes in the /sup 31/P-NMR spectra during the whole course of TET-induced edema. In the cerebral ischemia, no remarkable changes in the MRI were detected in either SE or IR images during the ischemic and recirculated periods. However, dynamic changes in the /sup 31/P-NMR spectra were detected during the course of cerebral ischemia. In the pre-ischemic period, the peaks of the ATP, PCr, phosphodiesters (PDE), Pi, and phosphomonoesters (PME) were detected. After the induction of ischemia, the ATP and PCr peaks decreased, while one Pi peak increased rapidly.}
journal = {CT Kenkyu; (Japan)}
volume = {9:1}
journal type = {AC}
place = {Japan}
year = {1987}
month = {Feb}
}