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Genetic heterogeneity of murine coronaviruses

Abstract

Several mouse hepatitis viruses (MHV) with different pathogenicity were studied by oligonucleotide fingerprinting. Two strains, MHV-K and MHV-D, which were isolated in Japan and, which cause anaplasia and necrosis of bone marrow and diarrhea, respectively, were found to be closely related to MHV-A59, the prototype MHV. Two other MHV strains, isolated from nude mice, were found to have diverged extensively from the known MHV strains. The MHVs isolated from separate cloned neuroblastoma cell lines persistently infected with JHM strain were also found to have diverged more markedly than the corresponding virus maintained under the conditions of lytic infection. Genetic divergence during persistent infection may be one of the mechanisms by which the MHV diverges.
Publication Date:
Dec 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-17-024801; EDB-86-074582
Resource Relation:
Journal Name: Arch. Virol.; (Austria); Journal Volume: 78:3-4
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; MICE; VIRAL DISEASES; VIRUSES; GENETIC VARIABILITY; AUTORADIOGRAPHY; BONE MARROW; CELL TRANSFORMATIONS; CLONE CELLS; DIARRHEA; ELECTROPHORESIS; GENES; GENETIC MAPPING; HEPATITIS; NECROSIS; NEOPLASMS; NERVOUS SYSTEM DISEASES; OLIGONUCLEOTIDES; PATHOGENS; PHOSPHORUS 32; TRACER TECHNIQUES; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL VARIABILITY; BODY; CELL CULTURES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM DISEASES; DISEASES; HEMATOPOIETIC SYSTEM; INFECTIOUS DISEASES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MAPPING; MICROORGANISMS; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PARASITES; PATHOLOGICAL CHANGES; PHOSPHORUS ISOTOPES; RADIOISOTOPES; RODENTS; SYMPTOMS; TISSUES; VERTEBRATES; 550701* - Microbiology- Tracer Techniques; 552001 - Public Health- Tracer Techniques
OSTI ID:
5895544
Research Organizations:
University of Southern California, Los Angeles, USA. Dept. of Microbiology; Tokyo Univ., Japan. School of Veterinary Science
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ARVID
Submitting Site:
INIS
Size:
Pages: 167-175
Announcement Date:

Citation Formats

Lai, M M.C., Fleming, J O, Stohlman, S A, and Fujiwara, K. Genetic heterogeneity of murine coronaviruses. Austria: N. p., 1983. Web. doi:10.1007/BF01311312.
Lai, M M.C., Fleming, J O, Stohlman, S A, & Fujiwara, K. Genetic heterogeneity of murine coronaviruses. Austria. doi:10.1007/BF01311312.
Lai, M M.C., Fleming, J O, Stohlman, S A, and Fujiwara, K. 1983. "Genetic heterogeneity of murine coronaviruses." Austria. doi:10.1007/BF01311312. https://www.osti.gov/servlets/purl/10.1007/BF01311312.
@misc{etde_5895544,
title = {Genetic heterogeneity of murine coronaviruses}
author = {Lai, M M.C., Fleming, J O, Stohlman, S A, and Fujiwara, K}
abstractNote = {Several mouse hepatitis viruses (MHV) with different pathogenicity were studied by oligonucleotide fingerprinting. Two strains, MHV-K and MHV-D, which were isolated in Japan and, which cause anaplasia and necrosis of bone marrow and diarrhea, respectively, were found to be closely related to MHV-A59, the prototype MHV. Two other MHV strains, isolated from nude mice, were found to have diverged extensively from the known MHV strains. The MHVs isolated from separate cloned neuroblastoma cell lines persistently infected with JHM strain were also found to have diverged more markedly than the corresponding virus maintained under the conditions of lytic infection. Genetic divergence during persistent infection may be one of the mechanisms by which the MHV diverges.}
doi = {10.1007/BF01311312}
journal = {Arch. Virol.; (Austria)}
volume = {78:3-4}
journal type = {AC}
place = {Austria}
year = {1983}
month = {Dec}
}