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Toxicity evaluation of chlorinated organic compounds using immortalized rat hepatocytes; Fushika rat kansaibo wo mochiita yuki enso kagobutsu no dokusei hyoka no kokoromi

Journal Article:

Abstract

Chlorinated organic compounds has high priority for toxicity screening among environmental hazardous chemicals. In the present study, we used immortalized rat hepatocytes as a liver model in vitro to evaluate the toxicity of nine chlorinated organic compounds. Toxicity of nine chlorinated organic compounds were evaluated to cellular viability of immortalized rat hapatocytes. The potency of the toxicity based on 50% inhibitory concentration (IC50) value was in the following order: triclocalban>triclosan>3,4-dichloroaniline>2,5-diclorophenol> 2,5-dichloroanisole>p-dichlorobenzene> p-chloroaniline>o-dichlorobenzene=tris (2-chloroethyl) phosphate. The rank order of cytotoxic potency of nine chemicals was compared with toxicity information using animals. The rank order of cytotoxic potency did not relative to the order referenced mean lethal dose (LD50) as an index of acute toxicity of rats or mice. However, the rank order of cytotoxic potency relatively correlated non-observed adverse effect level (NOAEL) under the exposure duration adjusted for chronic toxicity in vivo. These data suggests that the origin of testing cell had better to make match target organ of toxic chemicals for extrapolation from data of bioassay in vitro to in vivo. 16 refs., 2 figs., 3 tabs.
Authors:
Sone, H; Nakajima, M; Yonemoto, J [1] 
  1. National Institute for Environmental Studies, Tsukuba (Japan)
Publication Date:
Nov 10, 1997
Product Type:
Journal Article
Reference Number:
SCA: 540320; 540220; 290300; PA: JP-97:0G5333; EDB-98:054089; SN: 98001945522
Resource Relation:
Journal Name: Mizu Kankyo Gakkaishi (Journal of Japan Society on Water Environment); Journal Volume: 20; Journal Issue: 11; Other Information: PBD: 10 Nov 1997
Subject:
54 ENVIRONMENTAL SCIENCES; 29 ENERGY PLANNING AND POLICY; MICE; LIVER CELLS; MORTALITY; BIOASSAY; IN VITRO; IN VIVO; ORGANIC CHLORINE COMPOUNDS; TOXICITY; EVALUATION; SCREENING; HAZARDOUS MATERIALS; HEALTH HAZARDS; LETHAL DOSES; BIOLOGICAL EFFECTS; CHRONIC EXPOSURE
OSTI ID:
589196
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: MKGAEY; ISSN 0916-8958; TRN: JN97G5333
Submitting Site:
NEDO
Size:
pp. 99-106
Announcement Date:

Journal Article:

Citation Formats

Sone, H, Nakajima, M, and Yonemoto, J. Toxicity evaluation of chlorinated organic compounds using immortalized rat hepatocytes; Fushika rat kansaibo wo mochiita yuki enso kagobutsu no dokusei hyoka no kokoromi. Japan: N. p., 1997. Web.
Sone, H, Nakajima, M, & Yonemoto, J. Toxicity evaluation of chlorinated organic compounds using immortalized rat hepatocytes; Fushika rat kansaibo wo mochiita yuki enso kagobutsu no dokusei hyoka no kokoromi. Japan.
Sone, H, Nakajima, M, and Yonemoto, J. 1997. "Toxicity evaluation of chlorinated organic compounds using immortalized rat hepatocytes; Fushika rat kansaibo wo mochiita yuki enso kagobutsu no dokusei hyoka no kokoromi." Japan.
@misc{etde_589196,
title = {Toxicity evaluation of chlorinated organic compounds using immortalized rat hepatocytes; Fushika rat kansaibo wo mochiita yuki enso kagobutsu no dokusei hyoka no kokoromi}
author = {Sone, H, Nakajima, M, and Yonemoto, J}
abstractNote = {Chlorinated organic compounds has high priority for toxicity screening among environmental hazardous chemicals. In the present study, we used immortalized rat hepatocytes as a liver model in vitro to evaluate the toxicity of nine chlorinated organic compounds. Toxicity of nine chlorinated organic compounds were evaluated to cellular viability of immortalized rat hapatocytes. The potency of the toxicity based on 50% inhibitory concentration (IC50) value was in the following order: triclocalban>triclosan>3,4-dichloroaniline>2,5-diclorophenol> 2,5-dichloroanisole>p-dichlorobenzene> p-chloroaniline>o-dichlorobenzene=tris (2-chloroethyl) phosphate. The rank order of cytotoxic potency of nine chemicals was compared with toxicity information using animals. The rank order of cytotoxic potency did not relative to the order referenced mean lethal dose (LD50) as an index of acute toxicity of rats or mice. However, the rank order of cytotoxic potency relatively correlated non-observed adverse effect level (NOAEL) under the exposure duration adjusted for chronic toxicity in vivo. These data suggests that the origin of testing cell had better to make match target organ of toxic chemicals for extrapolation from data of bioassay in vitro to in vivo. 16 refs., 2 figs., 3 tabs.}
journal = {Mizu Kankyo Gakkaishi (Journal of Japan Society on Water Environment)}
issue = {11}
volume = {20}
journal type = {AC}
place = {Japan}
year = {1997}
month = {Nov}
}