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Semiquantitative diagnosis of cancer using short-lived radionuclides

Abstract

The accuracy and usefulness of semiquantitative diagnoses of SPECT using radiolabeled monoclonal antibodies in patients with colorectal cancer and PET using FDG in patients with recurrent lung cancer were investigated. The tumor to normal tissue count ratio (T/N ratio) was determined with SPECT and compared with the same index (T/N ratio) obtained by measuring radioactivity in tumor and normal tissue of the resected specimens. Significant correlation between SPECT T/N ratios and tissue T/N ratio was observed (r=0.92, p<0.001, n=8). In PET study, standardized uptake value (SUV) was obtained with PET images and assessed the difference in SUV between recurrent tumors and noncancerous lesions. The relationship between the SUV threshold and diagnostic accuracy in differentiating recurrent tumors from post-treatment changes was also assessed. The maximum SUV in recurrent tumor ranged from 3.0 to 25.8 with a mean {+-} s.d. of 11.2 {+-} 5.7 (n=16) and in the noncancerous lesion ranged from 2.0 to 7.5 with a mean {+-} s.d. of 3.5 {+-} 1.8 (n=9). The SUV was significantly higher in the recurrent cancer (P<0.0001). A threshold SUV of 5.0 provided optimal diagnostic accuracy (sensitivity 93.8%, specificity 88.9%, accuracy 92.0%). It was superior to visual interpretation of FDG PET (sensitivity 100%, specificity  More>>
Authors:
Inoue, Tomio; Oriuchi, Noboru; Endo, Keigo [1] 
  1. Gunma Univ., Maebashi (Japan). School of Medicine
Publication Date:
Mar 01, 1997
Product Type:
Conference
Report Number:
JAERI-Conf-97-003; CONF-9603254-
Reference Number:
SCA: 550601; PA: JPN-97:010094; EDB-98:040455; SN: 98001890437
Resource Relation:
Conference: 7. international symposium on advanced nuclear energy research, Takasaki (Japan), 18-20 Mar 1996; Other Information: PBD: Mar 1997; Related Information: Is Part Of Recent progress in accelerator beam application. Proceedings of the 7th international symposium on advanced nuclear energy research; PB: 553 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GALLIUM 68; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; FLUORINE 18; RADIOPHARMACEUTICALS; MONOCLONAL ANTIBODIES; RECTUM; CARCINOMAS; DIAGNOSTIC USES; PATIENTS; IMAGES; LUNGS; ACCURACY
OSTI ID:
588300
Research Organizations:
Japan Atomic Energy Research Inst., Tokyo (Japan)
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Other: ON: DE97764433; TRN: JP9710094
Availability:
OSTI as DE97764433
Submitting Site:
JPN
Size:
pp. 78-83
Announcement Date:

Citation Formats

Inoue, Tomio, Oriuchi, Noboru, and Endo, Keigo. Semiquantitative diagnosis of cancer using short-lived radionuclides. Japan: N. p., 1997. Web.
Inoue, Tomio, Oriuchi, Noboru, & Endo, Keigo. Semiquantitative diagnosis of cancer using short-lived radionuclides. Japan.
Inoue, Tomio, Oriuchi, Noboru, and Endo, Keigo. 1997. "Semiquantitative diagnosis of cancer using short-lived radionuclides." Japan.
@misc{etde_588300,
title = {Semiquantitative diagnosis of cancer using short-lived radionuclides}
author = {Inoue, Tomio, Oriuchi, Noboru, and Endo, Keigo}
abstractNote = {The accuracy and usefulness of semiquantitative diagnoses of SPECT using radiolabeled monoclonal antibodies in patients with colorectal cancer and PET using FDG in patients with recurrent lung cancer were investigated. The tumor to normal tissue count ratio (T/N ratio) was determined with SPECT and compared with the same index (T/N ratio) obtained by measuring radioactivity in tumor and normal tissue of the resected specimens. Significant correlation between SPECT T/N ratios and tissue T/N ratio was observed (r=0.92, p<0.001, n=8). In PET study, standardized uptake value (SUV) was obtained with PET images and assessed the difference in SUV between recurrent tumors and noncancerous lesions. The relationship between the SUV threshold and diagnostic accuracy in differentiating recurrent tumors from post-treatment changes was also assessed. The maximum SUV in recurrent tumor ranged from 3.0 to 25.8 with a mean {+-} s.d. of 11.2 {+-} 5.7 (n=16) and in the noncancerous lesion ranged from 2.0 to 7.5 with a mean {+-} s.d. of 3.5 {+-} 1.8 (n=9). The SUV was significantly higher in the recurrent cancer (P<0.0001). A threshold SUV of 5.0 provided optimal diagnostic accuracy (sensitivity 93.8%, specificity 88.9%, accuracy 92.0%). It was superior to visual interpretation of FDG PET (sensitivity 100%, specificity 55.6%, accuracy 84%). In conclusion, semiquantitative diagnoses with SPECT using radiolabeled monoclonal antibody and PET using FDG were accurate and useful in detecting malignant tumors. (author)}
place = {Japan}
year = {1997}
month = {Mar}
}