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Radiation damage to DNA: the effect of LET

Abstract

Mechanisms whereby ionizing radiation induced damage are introduced into cellular DNA are discussed. The types of lesions induced are summarized and the rationale is presented which supports the statement that radiation induced singly damaged sites are biologically unimportant. The conclusion that multiply damaged sites are critical is discussed and the mechanisms whereby such lesions are formed are presented. Structures of multiply damaged sites are summarized and problems which they present to cellular repair systems are discussed. Lastly the effects of linear energy transfer on the complexity of multiply damaged sites are surveyed and the consequences of this increased complexity are considered in terms of cell survival and mutation. (author)
Authors:
Ward, J F; Milligan, J R [1] 
  1. California Univ., San Diego, La Jolla, CA (United States). School of Medicine
Publication Date:
Mar 01, 1997
Product Type:
Conference
Report Number:
JAERI-Conf-97-003; CONF-9603254-
Reference Number:
SCA: 560120; PA: JPN-97:010091; EDB-98:040713; SN: 98001890434
Resource Relation:
Conference: 7. international symposium on advanced nuclear energy research, Takasaki (Japan), 18-20 Mar 1996; Other Information: PBD: Mar 1997; Related Information: Is Part Of Recent progress in accelerator beam application. Proceedings of the 7th international symposium on advanced nuclear energy research; PB: 553 p.
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; STRAND BREAKS; DNA; LET; HYDROXYL RADICALS; BIOLOGICAL RADIATION EFFECTS; DNA REPAIR; RBE; REVIEWS
OSTI ID:
588292
Research Organizations:
Japan Atomic Energy Research Inst., Tokyo (Japan)
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Other: ON: DE97764433; TRN: JP9710091
Availability:
OSTI as DE97764433
Submitting Site:
JPN
Size:
pp. 63-67
Announcement Date:
May 08, 1998

Citation Formats

Ward, J F, and Milligan, J R. Radiation damage to DNA: the effect of LET. Japan: N. p., 1997. Web.
Ward, J F, & Milligan, J R. Radiation damage to DNA: the effect of LET. Japan.
Ward, J F, and Milligan, J R. 1997. "Radiation damage to DNA: the effect of LET." Japan.
@misc{etde_588292,
title = {Radiation damage to DNA: the effect of LET}
author = {Ward, J F, and Milligan, J R}
abstractNote = {Mechanisms whereby ionizing radiation induced damage are introduced into cellular DNA are discussed. The types of lesions induced are summarized and the rationale is presented which supports the statement that radiation induced singly damaged sites are biologically unimportant. The conclusion that multiply damaged sites are critical is discussed and the mechanisms whereby such lesions are formed are presented. Structures of multiply damaged sites are summarized and problems which they present to cellular repair systems are discussed. Lastly the effects of linear energy transfer on the complexity of multiply damaged sites are surveyed and the consequences of this increased complexity are considered in terms of cell survival and mutation. (author)}
place = {Japan}
year = {1997}
month = {Mar}
}