Abstract
The interaction of cis-diamminediaquoplatinum(II) nitrate with adenosylcobalamin and a series of alkylcobalamins was studied by carbon-13 nuclear magnetic resonance spectroscopy and by electronic spectroscopy. With these cobalamins cis-(Pt(NH/sub 3/)/sub 2/(OH/sub 2/)/sub 2/)/sup 2 +/ forms adducts in which N(3) of the 5,6-methylbenzimidazole moiety is co-ordinated to platinum(II) rather than to cobalt(III) of the corrin. The chemical shifts of the 5'-methylene carbon of adenosylcobalamin-platinum adduct and of the Co-methyl carbon of the methylcobalamin-platinum adduct are characteristic of these cobalamins in the base-off form. Furthermore, these cobalamin-platinum complexes have visible spectra identical to those of the cobalamins in acidic solution. The /sup 13/C NMR spectrum of the adenosylcobalamin-platinum complex suggests the presence of a second adduct in which platinum(II) complexes are co-ordinated to both the N(3) of the 5,6-dimethylbenzimidazole nucleotide and to N(7) of the 5'-deoxyadenosyl moiety. The rate of the alkylcobalamin-platinum(II) adduct formation is determined by the strength of the cobalt(III)-5,6-dimethylbenzimidazole co-ordinate bond. Thus, adenosylcobalamin reacts much faster than adenosylepicobalamin to form the cobalamin-platinum(II) adduct.
Hogenkamp, H P.C.;
[1]
Kohlmiller, N A;
Howsinger, R;
Walker, T E;
Matwiyoff, N A
- Univ. of Minnesota, Minneapolis
Citation Formats
Hogenkamp, H P.C., Kohlmiller, N A, Howsinger, R, Walker, T E, and Matwiyoff, N A.
Interaction of cis-diamminediaquoplatinum(II) with adenosylcobalamin and alkylcobalamins.
United Kingdom: N. p.,
1980.
Web.
doi:10.1039/dt9800001668.
Hogenkamp, H P.C., Kohlmiller, N A, Howsinger, R, Walker, T E, & Matwiyoff, N A.
Interaction of cis-diamminediaquoplatinum(II) with adenosylcobalamin and alkylcobalamins.
United Kingdom.
https://doi.org/10.1039/dt9800001668
Hogenkamp, H P.C., Kohlmiller, N A, Howsinger, R, Walker, T E, and Matwiyoff, N A.
1980.
"Interaction of cis-diamminediaquoplatinum(II) with adenosylcobalamin and alkylcobalamins."
United Kingdom.
https://doi.org/10.1039/dt9800001668.
@misc{etde_5880033,
title = {Interaction of cis-diamminediaquoplatinum(II) with adenosylcobalamin and alkylcobalamins}
author = {Hogenkamp, H P.C., Kohlmiller, N A, Howsinger, R, Walker, T E, and Matwiyoff, N A}
abstractNote = {The interaction of cis-diamminediaquoplatinum(II) nitrate with adenosylcobalamin and a series of alkylcobalamins was studied by carbon-13 nuclear magnetic resonance spectroscopy and by electronic spectroscopy. With these cobalamins cis-(Pt(NH/sub 3/)/sub 2/(OH/sub 2/)/sub 2/)/sup 2 +/ forms adducts in which N(3) of the 5,6-methylbenzimidazole moiety is co-ordinated to platinum(II) rather than to cobalt(III) of the corrin. The chemical shifts of the 5'-methylene carbon of adenosylcobalamin-platinum adduct and of the Co-methyl carbon of the methylcobalamin-platinum adduct are characteristic of these cobalamins in the base-off form. Furthermore, these cobalamin-platinum complexes have visible spectra identical to those of the cobalamins in acidic solution. The /sup 13/C NMR spectrum of the adenosylcobalamin-platinum complex suggests the presence of a second adduct in which platinum(II) complexes are co-ordinated to both the N(3) of the 5,6-dimethylbenzimidazole nucleotide and to N(7) of the 5'-deoxyadenosyl moiety. The rate of the alkylcobalamin-platinum(II) adduct formation is determined by the strength of the cobalt(III)-5,6-dimethylbenzimidazole co-ordinate bond. Thus, adenosylcobalamin reacts much faster than adenosylepicobalamin to form the cobalamin-platinum(II) adduct.}
doi = {10.1039/dt9800001668}
journal = []
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Jan}
}
title = {Interaction of cis-diamminediaquoplatinum(II) with adenosylcobalamin and alkylcobalamins}
author = {Hogenkamp, H P.C., Kohlmiller, N A, Howsinger, R, Walker, T E, and Matwiyoff, N A}
abstractNote = {The interaction of cis-diamminediaquoplatinum(II) nitrate with adenosylcobalamin and a series of alkylcobalamins was studied by carbon-13 nuclear magnetic resonance spectroscopy and by electronic spectroscopy. With these cobalamins cis-(Pt(NH/sub 3/)/sub 2/(OH/sub 2/)/sub 2/)/sup 2 +/ forms adducts in which N(3) of the 5,6-methylbenzimidazole moiety is co-ordinated to platinum(II) rather than to cobalt(III) of the corrin. The chemical shifts of the 5'-methylene carbon of adenosylcobalamin-platinum adduct and of the Co-methyl carbon of the methylcobalamin-platinum adduct are characteristic of these cobalamins in the base-off form. Furthermore, these cobalamin-platinum complexes have visible spectra identical to those of the cobalamins in acidic solution. The /sup 13/C NMR spectrum of the adenosylcobalamin-platinum complex suggests the presence of a second adduct in which platinum(II) complexes are co-ordinated to both the N(3) of the 5,6-dimethylbenzimidazole nucleotide and to N(7) of the 5'-deoxyadenosyl moiety. The rate of the alkylcobalamin-platinum(II) adduct formation is determined by the strength of the cobalt(III)-5,6-dimethylbenzimidazole co-ordinate bond. Thus, adenosylcobalamin reacts much faster than adenosylepicobalamin to form the cobalamin-platinum(II) adduct.}
doi = {10.1039/dt9800001668}
journal = []
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Jan}
}