You need JavaScript to view this

Photosensitization of liposomes by porphyrins

Abstract

Lipid peroxidation was photosensitized in egg phosphatidylcholine (EPC) liposomes by hematoporphyrin (HP), hematoporphyrin derivative (HpD) and uroporphyrin I (Uro-I). Photosensitization by HP was type II via singlet oxygen (/sup 1/O/sub 2/) for the monomeric and dimeric states and type I for aggregated HP. Uro-I was an efficient type II /sup 1/O/sub 2/ photosensitizer. The HpD fraction enriched in the active biological component (HpD-A) was a type II /sup 1/O/sub 2/ photosensitizer at high and low concentrations. The spectral differences between HpD-A in buffer and solubilized in small EPC liposomes are attributed to a conformation change of a key dimer constituent from a folded to a planar geometry. The implications of the results for the action mechanism in photoradiation therapy of tumors with these porphyrins are discussed. 73 references, 1 figure, 5 tables.
Publication Date:
Jan 01, 1984
Product Type:
Conference
Reference Number:
EDB-86-081779
Resource Relation:
Journal Name: J. Photochem.; (Switzerland); Journal Volume: 25; Conference: Cosmo 84 conference on singlet molecular oxygen, Clearwater Beach, FL, USA, 4-7 Jan 1984
Subject:
59 BASIC BIOLOGICAL SCIENCES; LIPOSOMES; PHOTOSENSITIVITY; NEOPLASMS; THERAPY; PORPHYRINS; BIOLOGICAL LOCALIZATION; CELL MEMBRANES; EXPERIMENTAL DATA; LIPIDS; OXYGEN; CARBOXYLIC ACIDS; CELL CONSTITUENTS; DATA; DISEASES; ELEMENTS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INFORMATION; MEMBRANES; NONMETALS; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANOIDS; SENSITIVITY; 550900* - Pathology
OSTI ID:
5878497
Research Organizations:
Illinois Institute of Technology, Chicago
Country of Origin:
Switzerland
Language:
English
Contract Number:
AC02-76EV02217
Other Identifying Numbers:
Journal ID: CODEN: JPCMA
Submitting Site:
JMT
Size:
Pages: 253-265
Announcement Date:

Citation Formats

Grossweiner, L I, and Goyal, G C. Photosensitization of liposomes by porphyrins. Switzerland: N. p., 1984. Web.
Grossweiner, L I, & Goyal, G C. Photosensitization of liposomes by porphyrins. Switzerland.
Grossweiner, L I, and Goyal, G C. 1984. "Photosensitization of liposomes by porphyrins." Switzerland.
@misc{etde_5878497,
title = {Photosensitization of liposomes by porphyrins}
author = {Grossweiner, L I, and Goyal, G C}
abstractNote = {Lipid peroxidation was photosensitized in egg phosphatidylcholine (EPC) liposomes by hematoporphyrin (HP), hematoporphyrin derivative (HpD) and uroporphyrin I (Uro-I). Photosensitization by HP was type II via singlet oxygen (/sup 1/O/sub 2/) for the monomeric and dimeric states and type I for aggregated HP. Uro-I was an efficient type II /sup 1/O/sub 2/ photosensitizer. The HpD fraction enriched in the active biological component (HpD-A) was a type II /sup 1/O/sub 2/ photosensitizer at high and low concentrations. The spectral differences between HpD-A in buffer and solubilized in small EPC liposomes are attributed to a conformation change of a key dimer constituent from a folded to a planar geometry. The implications of the results for the action mechanism in photoradiation therapy of tumors with these porphyrins are discussed. 73 references, 1 figure, 5 tables.}
journal = {J. Photochem.; (Switzerland)}
volume = {25}
place = {Switzerland}
year = {1984}
month = {Jan}
}