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Peripheral blood leukocyte phagocytosis and respiratory response to certain macromolecular substances in the ABCC-JNIH adult health study, Hiroshima

Abstract

The functional integrity of the peripheral blood leukocytes of 10 heavily exposed subjects and 10 matched controls was evaluated by measuring oxygen consumption following the addition of latex particles and E. coli endotoxin, and measuring sensitized and unsensitized starch granule phagocytosis. There was no significant difference in the responses of leukocytes from exposed subjects and controls following the addition of latex particles. The ultimate response of leukocytes from exposed subjects to the stimulus of E. coli endotoxin was comparable to that of the controls. Depressed early response in 5 of 10 exposed and 1 of 10 control subjects was observed. Interpretation is unclear. No evidence of radiation-related impairment of starch granule phagocytosis was observed. Results fail to demonstrate any late radiation-related functional impairment of peripheral blood leukocytes during phagocytosis. The serum-related changes were inconstant and probably were of little significance. (auth)
Publication Date:
Jan 01, 1974
Product Type:
Technical Report
Report Number:
ABCC-TR-8-74
Reference Number:
EDB-80-006918
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; BIOLOGICAL RADIATION EFFECTS; DELAYED RADIATION EFFECTS; LEUKOCYTES; PHAGOCYTOSIS; ENDOTOXINS; HIROSHIMA; IN VITRO; PARTICLES; SAMPLING; STARCH; TESTING; ANTIGENS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; JAPAN; ORGANIC COMPOUNDS; POLYSACCHARIDES; RADIATION EFFECTS; REAGENTS; SACCHARIDES; TOXIC MATERIALS; TOXINS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5867937
Research Organizations:
Atomic Bomb Casualty Commission, Hiroshima (Japan); Atomic Bomb Casualty Commission, Nagasaki (Japan)
Country of Origin:
Japan
Language:
English
Contract Number:
EX-76-C-28-3161
Availability:
Dep. NTIS, PC A02/MF A01.
Submitting Site:
NEDO
Size:
Pages: 20
Announcement Date:
May 13, 2001

Citation Formats

Barerras, R F, and Finch, S C. Peripheral blood leukocyte phagocytosis and respiratory response to certain macromolecular substances in the ABCC-JNIH adult health study, Hiroshima. Japan: N. p., 1974. Web.
Barerras, R F, & Finch, S C. Peripheral blood leukocyte phagocytosis and respiratory response to certain macromolecular substances in the ABCC-JNIH adult health study, Hiroshima. Japan.
Barerras, R F, and Finch, S C. 1974. "Peripheral blood leukocyte phagocytosis and respiratory response to certain macromolecular substances in the ABCC-JNIH adult health study, Hiroshima." Japan.
@misc{etde_5867937,
title = {Peripheral blood leukocyte phagocytosis and respiratory response to certain macromolecular substances in the ABCC-JNIH adult health study, Hiroshima}
author = {Barerras, R F, and Finch, S C}
abstractNote = {The functional integrity of the peripheral blood leukocytes of 10 heavily exposed subjects and 10 matched controls was evaluated by measuring oxygen consumption following the addition of latex particles and E. coli endotoxin, and measuring sensitized and unsensitized starch granule phagocytosis. There was no significant difference in the responses of leukocytes from exposed subjects and controls following the addition of latex particles. The ultimate response of leukocytes from exposed subjects to the stimulus of E. coli endotoxin was comparable to that of the controls. Depressed early response in 5 of 10 exposed and 1 of 10 control subjects was observed. Interpretation is unclear. No evidence of radiation-related impairment of starch granule phagocytosis was observed. Results fail to demonstrate any late radiation-related functional impairment of peripheral blood leukocytes during phagocytosis. The serum-related changes were inconstant and probably were of little significance. (auth)}
place = {Japan}
year = {1974}
month = {Jan}
}