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Pathological studies on carcinoma of the lung in rats induced by external x-ray irradiation

Journal Article:

Abstract

Lung tumors in Wistar rats were induced by administration of various doses of external irradiation through the anterior chest wall. Pulmonary fibrosis following external irradiation was observed in 13 of 17 rats (76.4%) in Group I (800R/day for 5 days), in 26 of 36 rats (78.8%) in Group II (800R/WK for 5 WKs), and in 6 of 18 rats (35.3%) in Group III (500R/WK for 4 WKs). The degree of pulmonary fibrosis was greater each time in the rats given 4,000R than in the rats given 2,000R. In Groups I and II 5 pulmonary tumors (2 squamous cell carcinomas, 1 adenocarcinoma, and 2 adenomas) were observed in 3 of 16 rats (17.6%), and 10 pulmonary tumors (4 squamous cell carcinomas, 1 adenocarcinoma, 4 adenomas, and 1 fibrosarcoma) were observed in 9 of 33 rats (24.2%), respectively. In Group III only 1 case of pulmonary adenoma was observed among 17 rats (6.8%). The first case of epithelial tumor of the lung was found in a rat in Group I. Histological findings during the course of the experiment revealed that the earliest changes following irradiation were those of radiation pneuminitis, characterized by engorged capillaries and edema in collapsed alveoli, with lymphocytic and  More>>
Authors:
Kodama, T [1] 
  1. Hiroshima Univ. (Japan). School of Medicine
Publication Date:
Aug 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-469644; EDB-80-007115
Resource Relation:
Journal Name: Med. J. Hiroshima Univ.; (Japan); Journal Volume: 26:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; RADIOINDUCTION; LUNGS; DELAYED RADIATION EFFECTS; CARCINOGENESIS; FIBROSIS; FRACTIONATED IRRADIATION; LOCAL IRRADIATION; MORPHOLOGICAL CHANGES; PNEUMONITIS; RATS; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NEOPLASMS; ORGANS; PATHOGENESIS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5867664
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HDIZA
Submitting Site:
INIS
Size:
Pages: 289-329
Announcement Date:

Journal Article:

Citation Formats

Kodama, T. Pathological studies on carcinoma of the lung in rats induced by external x-ray irradiation. Japan: N. p., 1978. Web.
Kodama, T. Pathological studies on carcinoma of the lung in rats induced by external x-ray irradiation. Japan.
Kodama, T. 1978. "Pathological studies on carcinoma of the lung in rats induced by external x-ray irradiation." Japan.
@misc{etde_5867664,
title = {Pathological studies on carcinoma of the lung in rats induced by external x-ray irradiation}
author = {Kodama, T}
abstractNote = {Lung tumors in Wistar rats were induced by administration of various doses of external irradiation through the anterior chest wall. Pulmonary fibrosis following external irradiation was observed in 13 of 17 rats (76.4%) in Group I (800R/day for 5 days), in 26 of 36 rats (78.8%) in Group II (800R/WK for 5 WKs), and in 6 of 18 rats (35.3%) in Group III (500R/WK for 4 WKs). The degree of pulmonary fibrosis was greater each time in the rats given 4,000R than in the rats given 2,000R. In Groups I and II 5 pulmonary tumors (2 squamous cell carcinomas, 1 adenocarcinoma, and 2 adenomas) were observed in 3 of 16 rats (17.6%), and 10 pulmonary tumors (4 squamous cell carcinomas, 1 adenocarcinoma, 4 adenomas, and 1 fibrosarcoma) were observed in 9 of 33 rats (24.2%), respectively. In Group III only 1 case of pulmonary adenoma was observed among 17 rats (6.8%). The first case of epithelial tumor of the lung was found in a rat in Group I. Histological findings during the course of the experiment revealed that the earliest changes following irradiation were those of radiation pneuminitis, characterized by engorged capillaries and edema in collapsed alveoli, with lymphocytic and plasma cell infiltrations. In addition, the nuclei of the lining cells of the alveoli and bronchioles were enlarged and atypical. From the 10th through the 20th experimental week, fibrosis of the alveolar septum and adenomatous hyperplasia of the alveolar lining became extensive, particularly in the bronchiolo-alveolar areas of the periphery of the lung. Atypical adenomatous hyperplasia occurred within the fibrotic lesion or in proximity to it. It was frequently followed by carcinoma, suggesting that carcinoma in the present experiment arose in atypical epithelium, induced by irradiation of the bronchiolo-alveolar epithelial lining.}
journal = {Med. J. Hiroshima Univ.; (Japan)}
volume = {26:4}
journal type = {AC}
place = {Japan}
year = {1978}
month = {Aug}
}