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Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay]

Abstract

Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined.
Authors:
Adolfsson, R; Alafuzoff, I; Winblad, B; [1]  Perdahl, E; Albert, K A; Nestler, E J; Greengard, P [2] 
  1. Umeaa Univ. (Sweden)
  2. Rockefeller Univ., New York (USA)
Publication Date:
Jan 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-16-010141; EDB-85-080229
Resource Relation:
Journal Name: J. Neural Transm.; (Austria); Journal Volume: 60:2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NERVOUS SYSTEM DISEASES; DIAGNOSIS; AUTOPSY; CEREBRUM; COMPARATIVE EVALUATIONS; HIPPOCAMPUS; MENTAL DISORDERS; NERVE CELLS; ORGANIC PHOSPHORUS COMPOUNDS; PATIENTS; PROTEINS; QUANTITY RATIO; RADIOIMMUNOASSAY; RECEPTORS; ANIMAL CELLS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; ISOTOPE APPLICATIONS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; RADIOASSAY; SOMATIC CELLS; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5863781
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JNTMA
Submitting Site:
HEDB
Size:
Pages: 133-141
Announcement Date:
Feb 01, 1985

Citation Formats

Adolfsson, R, Alafuzoff, I, Winblad, B, Perdahl, E, Albert, K A, Nestler, E J, and Greengard, P. Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay]. Austria: N. p., 1984. Web.
Adolfsson, R, Alafuzoff, I, Winblad, B, Perdahl, E, Albert, K A, Nestler, E J, & Greengard, P. Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay]. Austria.
Adolfsson, R, Alafuzoff, I, Winblad, B, Perdahl, E, Albert, K A, Nestler, E J, and Greengard, P. 1984. "Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay]." Austria.
@misc{etde_5863781,
title = {Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay]}
author = {Adolfsson, R, Alafuzoff, I, Winblad, B, Perdahl, E, Albert, K A, Nestler, E J, and Greengard, P}
abstractNote = {Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined.}
journal = []
volume = {60:2}
journal type = {AC}
place = {Austria}
year = {1984}
month = {Jan}
}