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Tritium metabolism in newborn mice and estimation of the accumulated dose

Abstract

Suckling mice received tritium from their mothers who were supplied with tritiated water as drinking water. After weaning, the offspring were sacrificed and the tritium concentration was determined for various organs and various molecular components including acid soluble component, lipid, RNA, DNA and protein. The accumulated dose for the period between 3 and 41 weeks after birth was calculated for various organs and the contributions of the acid insoluble components to the total dose estimated. The per cent contribution of the acid insoluble components to the total dose was organ specific and was between about 17% and 42%. The result indicates that the inhomogeneous distribution of tritium in subcellular structures needs to be taken into account. The contribution of organically bound tritium to dose is then comparable to that of tritium in the free water component.
Publication Date:
Jan 01, 1986
Product Type:
Conference
Report Number:
CONF-860214-
Reference Number:
GBN-87-000658; EDB-88-022104
Resource Relation:
Journal Name: Radiat. Prot. Dosim.; (United Kingdom); Journal Volume: 16:1-2; Conference: Workshop on environmental and human risks of tritium, Karlsruhe, F.R. Germany, 17 Feb 1986
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TRITIUM; NEONATES; RADIONUCLIDE KINETICS; BIOLOGICAL HALF-LIFE; DNA; DRINKING WATER; HEAVY WATER; LIPIDS; MICE; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIATION DOSES; RETENTION; RNA; TRITIUM COMPOUNDS; TRITIUM OXIDES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CHALCOGENIDES; DOSES; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; OXIDES; OXYGEN COMPOUNDS; RADIOISOTOPES; RODENTS; VERTEBRATES; WATER; YEARS LIVING RADIOISOTOPES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells
OSTI ID:
5845184
Research Organizations:
Kyoto Univ., Kumatori, Osaka, Japan. Research Reactor Inst.
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: RPDOD
Submitting Site:
GBN
Size:
Pages: 131-134
Announcement Date:
May 13, 2001

Citation Formats

Saito, M, and Ishida, M R. Tritium metabolism in newborn mice and estimation of the accumulated dose. United Kingdom: N. p., 1986. Web.
Saito, M, & Ishida, M R. Tritium metabolism in newborn mice and estimation of the accumulated dose. United Kingdom.
Saito, M, and Ishida, M R. 1986. "Tritium metabolism in newborn mice and estimation of the accumulated dose." United Kingdom.
@misc{etde_5845184,
title = {Tritium metabolism in newborn mice and estimation of the accumulated dose}
author = {Saito, M, and Ishida, M R}
abstractNote = {Suckling mice received tritium from their mothers who were supplied with tritiated water as drinking water. After weaning, the offspring were sacrificed and the tritium concentration was determined for various organs and various molecular components including acid soluble component, lipid, RNA, DNA and protein. The accumulated dose for the period between 3 and 41 weeks after birth was calculated for various organs and the contributions of the acid insoluble components to the total dose estimated. The per cent contribution of the acid insoluble components to the total dose was organ specific and was between about 17% and 42%. The result indicates that the inhomogeneous distribution of tritium in subcellular structures needs to be taken into account. The contribution of organically bound tritium to dose is then comparable to that of tritium in the free water component.}
journal = []
volume = {16:1-2}
place = {United Kingdom}
year = {1986}
month = {Jan}
}