You need JavaScript to view this

Experiment designed to measure the RBE of tritium for the induction of myeloid leukaemia in animals

Conference:

Abstract

The range in RBE vales measured for tritium can be attributed to differences in the biological endpoints measured, the reference radiation to which the effects of tritium were compared, and the tritium dosimetry of the particular study. Since the principal risk of low-level irradiation is the induction of cancers, it would be desirable to utilise this endpoint in tritium RBE experiments if these experiments are to be used to evaluate the quality factor for tritium. Furthermore, it would be desirable to use 200 k Vp X rays as the reference radiation since this radiation was suggested by ICRP as the standard reference to be used in the calculation of dose equivalents. Acute myeloid leukaemia is one of the earliest recognised examples of radiogenic cancer in humans and this endpoint has also been the subject of animal studies. A brief review is given of these animal studies to see if this endpoint is suitable for an experiment to measure the tritium RBE relative to 200 k Vp X rays. It was concluded that the male CBA/H mouse would be a suitable species and an experiment involving 5000 animals in four to five year study would be required to provide a useful  More>>
Publication Date:
Jan 01, 1986
Product Type:
Conference
Report Number:
CONF-860214-
Reference Number:
GBN-87-000664; EDB-88-022110
Resource Relation:
Journal Name: Radiat. Prot. Dosim.; (United Kingdom); Journal Volume: 16:1-2; Conference: Workshop on environmental and human risks of tritium, Karlsruhe, F.R. Germany, 17 Feb 1986
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RBE; TRITIUM; MYELOID LEUKEMIA; ANIMALS; BIOLOGICAL RADIATION EFFECTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; DISEASES; HEMIC DISEASES; HYDROGEN ISOTOPES; ISOTOPES; LEUKEMIA; LIGHT NUCLEI; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells
OSTI ID:
5845172
Research Organizations:
Atomic Energy of Canada Ltd., Chalk River, Ontario. Chalk River Nuclear Labs.
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: RPDOD
Submitting Site:
GBN
Size:
Pages: 161-164
Announcement Date:

Conference:

Citation Formats

Johnson, J R, Myers, D K, and Gragtmans, N J. Experiment designed to measure the RBE of tritium for the induction of myeloid leukaemia in animals. United Kingdom: N. p., 1986. Web.
Johnson, J R, Myers, D K, & Gragtmans, N J. Experiment designed to measure the RBE of tritium for the induction of myeloid leukaemia in animals. United Kingdom.
Johnson, J R, Myers, D K, and Gragtmans, N J. 1986. "Experiment designed to measure the RBE of tritium for the induction of myeloid leukaemia in animals." United Kingdom.
@misc{etde_5845172,
title = {Experiment designed to measure the RBE of tritium for the induction of myeloid leukaemia in animals}
author = {Johnson, J R, Myers, D K, and Gragtmans, N J}
abstractNote = {The range in RBE vales measured for tritium can be attributed to differences in the biological endpoints measured, the reference radiation to which the effects of tritium were compared, and the tritium dosimetry of the particular study. Since the principal risk of low-level irradiation is the induction of cancers, it would be desirable to utilise this endpoint in tritium RBE experiments if these experiments are to be used to evaluate the quality factor for tritium. Furthermore, it would be desirable to use 200 k Vp X rays as the reference radiation since this radiation was suggested by ICRP as the standard reference to be used in the calculation of dose equivalents. Acute myeloid leukaemia is one of the earliest recognised examples of radiogenic cancer in humans and this endpoint has also been the subject of animal studies. A brief review is given of these animal studies to see if this endpoint is suitable for an experiment to measure the tritium RBE relative to 200 k Vp X rays. It was concluded that the male CBA/H mouse would be a suitable species and an experiment involving 5000 animals in four to five year study would be required to provide a useful estimate of the RBE for tritium.}
journal = {Radiat. Prot. Dosim.; (United Kingdom)}
volume = {16:1-2}
place = {United Kingdom}
year = {1986}
month = {Jan}
}