Abstract
(S)-2-Hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide ((S)-BZM), the precursor of (S)-2-hydroxy-3-{sup 123}I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl )benzamide ((S)-{sup 123}I-IBZM) was synthesized via a simple method and in high yield starting from 2,6-dimethoxybenzoic acid (1a). N-Hydroxysuccinimide/dicyclohexyl-carbodiimide (DCC) was used as activating system in the reaction of 2,6-dimethoxybenzoic acid with (S)-2-aminomethyl-1-ethylpyrrolidine. (author).
Bobeldijk, M;
Doremalen, P.A.P.M. van;
Hoof, J.J. van;
Janssen, A G.M.;
[1]
Verhoeff, N P.L.G.;
Vekemans, J A.J.M.;
Buck, H M
[2]
- Technische Univ. Eindhoven (Netherlands) Cygne B.V., Eindhoven (Netherlands)
- Technische Univ. Eindhoven (Netherlands)
Citation Formats
Bobeldijk, M, Doremalen, P.A.P.M. van, Hoof, J.J. van, Janssen, A G.M., Verhoeff, N P.L.G., Vekemans, J A.J.M., and Buck, H M.
A simple and high-yield synthesis of (S)-BZM, (R)-BZM and (S)-IBZM for the preparation of (S)- sup 123 I-IBZM. [(S)-2-hydroxy-3- sup 123 I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methy l)benzamide].
United Kingdom: N. p.,
1990.
Web.
doi:10.1002/jlcr.2580281104.
Bobeldijk, M, Doremalen, P.A.P.M. van, Hoof, J.J. van, Janssen, A G.M., Verhoeff, N P.L.G., Vekemans, J A.J.M., & Buck, H M.
A simple and high-yield synthesis of (S)-BZM, (R)-BZM and (S)-IBZM for the preparation of (S)- sup 123 I-IBZM. [(S)-2-hydroxy-3- sup 123 I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methy l)benzamide].
United Kingdom.
https://doi.org/10.1002/jlcr.2580281104
Bobeldijk, M, Doremalen, P.A.P.M. van, Hoof, J.J. van, Janssen, A G.M., Verhoeff, N P.L.G., Vekemans, J A.J.M., and Buck, H M.
1990.
"A simple and high-yield synthesis of (S)-BZM, (R)-BZM and (S)-IBZM for the preparation of (S)- sup 123 I-IBZM. [(S)-2-hydroxy-3- sup 123 I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methy l)benzamide]."
United Kingdom.
https://doi.org/10.1002/jlcr.2580281104.
@misc{etde_5843683,
title = {A simple and high-yield synthesis of (S)-BZM, (R)-BZM and (S)-IBZM for the preparation of (S)- sup 123 I-IBZM. [(S)-2-hydroxy-3- sup 123 I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methy l)benzamide]}
author = {Bobeldijk, M, Doremalen, P.A.P.M. van, Hoof, J.J. van, Janssen, A G.M., Verhoeff, N P.L.G., Vekemans, J A.J.M., and Buck, H M}
abstractNote = {(S)-2-Hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide ((S)-BZM), the precursor of (S)-2-hydroxy-3-{sup 123}I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl )benzamide ((S)-{sup 123}I-IBZM) was synthesized via a simple method and in high yield starting from 2,6-dimethoxybenzoic acid (1a). N-Hydroxysuccinimide/dicyclohexyl-carbodiimide (DCC) was used as activating system in the reaction of 2,6-dimethoxybenzoic acid with (S)-2-aminomethyl-1-ethylpyrrolidine. (author).}
doi = {10.1002/jlcr.2580281104}
journal = []
volume = {28:11}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Nov}
}
title = {A simple and high-yield synthesis of (S)-BZM, (R)-BZM and (S)-IBZM for the preparation of (S)- sup 123 I-IBZM. [(S)-2-hydroxy-3- sup 123 I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methy l)benzamide]}
author = {Bobeldijk, M, Doremalen, P.A.P.M. van, Hoof, J.J. van, Janssen, A G.M., Verhoeff, N P.L.G., Vekemans, J A.J.M., and Buck, H M}
abstractNote = {(S)-2-Hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide ((S)-BZM), the precursor of (S)-2-hydroxy-3-{sup 123}I-iodo-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl )benzamide ((S)-{sup 123}I-IBZM) was synthesized via a simple method and in high yield starting from 2,6-dimethoxybenzoic acid (1a). N-Hydroxysuccinimide/dicyclohexyl-carbodiimide (DCC) was used as activating system in the reaction of 2,6-dimethoxybenzoic acid with (S)-2-aminomethyl-1-ethylpyrrolidine. (author).}
doi = {10.1002/jlcr.2580281104}
journal = []
volume = {28:11}
journal type = {AC}
place = {United Kingdom}
year = {1990}
month = {Nov}
}