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Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation

Journal Article:

Abstract

Fourteen patients with chronic granulocytic leukemia received bone marrow grafts from HLA identical siblings. Ten patients were in blast crisis prior to grafting, three were in an accelerated phase of their disease, and one was aplastic secondary to chemotherapy. Prior to transplant all patients were conditioned with chemotherapy including cyclophosphamide plus 1,000 rad of total body irradiation. Ten patients achieved engraftment while four died 1 to 26 days after marrow infusion without functioning grafts. Two patients reveived a second infusion of donor marrow because of delayed engraftment. Neither marrow cell dose nor presence of myelofibrosis correlated with succesful engraftment. Three out of ten engrafted patients developed graft-versus-host disease. Interstitial pneumonia occurred in seven patients. The immediate cause of death was bacterial septicemia in six patients. All evidence of leukemia disappeared in nine out of ten evaluable patients. The median survival was 43 days. One patient had a complete remission of 16 months duration.
Authors:
Doney, K; Buckner, C D; Sale, G E; Ramberg, R; Boyd, C; Thomas, E D; [1]  Washington Univ., Seattle (USA). School of Medicine)
  1. Fred Hutchinson Cancer Research Institute
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-458984; EDB-80-018287
Resource Relation:
Journal Name: Exp. Hematol.; (Denmark); Journal Volume: 6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW CELLS; GRAFTS; IMMUNE REACTIONS; BIOLOGICAL RADIATION EFFECTS; LEUKEMIA; CHEMOTHERAPY; ENDOXAN; PATIENTS; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANIMAL CELLS; ANTIMITOTIC DRUGS; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; EXTERNAL IRRADIATION; HEMIC DISEASES; IRRADIATION; NEOPLASMS; RADIATION EFFECTS; SOMATIC CELLS; THERAPY; TRANSPLANTS; 560151* - Radiation Effects on Animals- Man; 550600 - Medicine
OSTI ID:
5829897
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXHEB
Submitting Site:
INIS
Size:
Pages: 738-747
Announcement Date:

Journal Article:

Citation Formats

Doney, K, Buckner, C D, Sale, G E, Ramberg, R, Boyd, C, Thomas, E D, and Washington Univ., Seattle (USA). School of Medicine). Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation. Denmark: N. p., 1978. Web.
Doney, K, Buckner, C D, Sale, G E, Ramberg, R, Boyd, C, Thomas, E D, & Washington Univ., Seattle (USA). School of Medicine). Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation. Denmark.
Doney, K, Buckner, C D, Sale, G E, Ramberg, R, Boyd, C, Thomas, E D, and Washington Univ., Seattle (USA). School of Medicine). 1978. "Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation." Denmark.
@misc{etde_5829897,
title = {Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation}
author = {Doney, K, Buckner, C D, Sale, G E, Ramberg, R, Boyd, C, Thomas, E D, and Washington Univ., Seattle (USA). School of Medicine)}
abstractNote = {Fourteen patients with chronic granulocytic leukemia received bone marrow grafts from HLA identical siblings. Ten patients were in blast crisis prior to grafting, three were in an accelerated phase of their disease, and one was aplastic secondary to chemotherapy. Prior to transplant all patients were conditioned with chemotherapy including cyclophosphamide plus 1,000 rad of total body irradiation. Ten patients achieved engraftment while four died 1 to 26 days after marrow infusion without functioning grafts. Two patients reveived a second infusion of donor marrow because of delayed engraftment. Neither marrow cell dose nor presence of myelofibrosis correlated with succesful engraftment. Three out of ten engrafted patients developed graft-versus-host disease. Interstitial pneumonia occurred in seven patients. The immediate cause of death was bacterial septicemia in six patients. All evidence of leukemia disappeared in nine out of ten evaluable patients. The median survival was 43 days. One patient had a complete remission of 16 months duration.}
journal = {Exp. Hematol.; (Denmark)}
volume = {6}
journal type = {AC}
place = {Denmark}
year = {1978}
month = {Jan}
}