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Passive inhalation of cannabis smoke

Abstract

Six volunteers each smoked simultaneously, in a small unventilated room (volume 27 950 liter), a cannabis cigarette containing 17.1 mg delta 9-tetrahydrocannabinol (THC). A further four subjects - passive inhalers - remained in the room during smoking and afterwards for a total of 3 h. Blood and urine samples were taken from all ten subjects and analyzed by radioimmunoassay for THC metabolites. The blood samples from the passive subjects taken up to 3 h after the start of exposure to cannabis smoke showed a complete absence of cannabinoids. In contrast, their urine samples taken up to 6 h after exposure showed significant concentrations of cannabinoid metabolites (less than or equal to 6.8 ng ml-1). These data, taken with the results of other workers, show passive inhalation of cannabis smoke to be possible. These results have important implications for forensic toxicologists who are frequently called upon to interpret cannabinoid levels in body fluids.
Publication Date:
Sep 01, 1984
Product Type:
Journal Article
Reference Number:
EDB-85-088427
Resource Relation:
Journal Name: J. Pharm. Pharmacol.; (United Kingdom); Journal Volume: 36:9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD; RADIOIMMUNOASSAY; MARIHUANA; DETECTION; URINE; AIR POLLUTION; DRUG ABUSE; INHALATION; METABOLISM; SMOKES; AEROSOLS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; COLLOIDS; DISPERSIONS; HERBS; INTAKE; ISOTOPE APPLICATIONS; MATERIALS; PLANTS; POLLUTION; RADIOASSAY; RESIDUES; SOLS; TRACER TECHNIQUES; WASTES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5828017
Research Organizations:
Home Office Forensic Science Service, Aldermaston, Reading, Berks, England
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JPPMA
Submitting Site:
HEDB
Size:
Pages: 578-581
Announcement Date:
Feb 01, 1985

Citation Formats

Law, B, Mason, P A, Moffat, A C, King, L J, and Marks, V. Passive inhalation of cannabis smoke. United Kingdom: N. p., 1984. Web.
Law, B, Mason, P A, Moffat, A C, King, L J, & Marks, V. Passive inhalation of cannabis smoke. United Kingdom.
Law, B, Mason, P A, Moffat, A C, King, L J, and Marks, V. 1984. "Passive inhalation of cannabis smoke." United Kingdom.
@misc{etde_5828017,
title = {Passive inhalation of cannabis smoke}
author = {Law, B, Mason, P A, Moffat, A C, King, L J, and Marks, V}
abstractNote = {Six volunteers each smoked simultaneously, in a small unventilated room (volume 27 950 liter), a cannabis cigarette containing 17.1 mg delta 9-tetrahydrocannabinol (THC). A further four subjects - passive inhalers - remained in the room during smoking and afterwards for a total of 3 h. Blood and urine samples were taken from all ten subjects and analyzed by radioimmunoassay for THC metabolites. The blood samples from the passive subjects taken up to 3 h after the start of exposure to cannabis smoke showed a complete absence of cannabinoids. In contrast, their urine samples taken up to 6 h after exposure showed significant concentrations of cannabinoid metabolites (less than or equal to 6.8 ng ml-1). These data, taken with the results of other workers, show passive inhalation of cannabis smoke to be possible. These results have important implications for forensic toxicologists who are frequently called upon to interpret cannabinoid levels in body fluids.}
journal = []
volume = {36:9}
journal type = {AC}
place = {United Kingdom}
year = {1984}
month = {Sep}
}