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Tumor and liver uptake models of /sup 67/Ga-citrate

Journal Article:

Abstract

After administration /sup 67/Ga concentrates with time in lysosomes from the cytoplasm of liver cells. The lysosomal role in the accumulation of /sup 67/Ga in the liver cell is weakened upon transformation of the liver cell into a malignant tumor cell. In malignant tumors (except for hepatoma) the lysosome does not play a major role in the tumor concentration of /sup 67/Ga. /sup 67/Ga is bound to acid mucopolysaccharides (keratan polysulfate, etc.) in both tumor and liver. In liver cells, large amounts of /sup 67/Ga are transported into lysosomes with these acid mucopolysaccharides, and in hepatoma cells, quite large amounts of /sup 67/Ga are transported into lysosomes with these acid mucopolysaccharides. In malignant tumor cells (except for hepatoma) the effect is much smaller, the acid mucopolysaccharides transporting very little /sup 67/Ga into lysosome. The /sup 67/Ga is concentrated in viable tumor tissue within malignant tissue but hardly at all in necrotic tumor tissue, and concentrates avidly in inflammatory infiltration around tumor cells. Plenty of /sup 67/Ga is found in liver but very little in connective tissue associated with the liver.
Publication Date:
Mar 01, 1985
Product Type:
Journal Article
Reference Number:
FRG-84-03567; EDB-85-089103
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 10:5/6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GALLIUM 67; UPTAKE; LIVER CELLS; RADIONUCLIDE KINETICS; TUMOR CELLS; CITRATES; CONNECTIVE TISSUE; EXPERIMENTAL NEOPLASMS; GALLIUM COMPOUNDS; LIVER; LYSOSOMES; RADIOPHARMACEUTICALS; RATS; TRANSPLANTS; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACID SALTS; CELL CONSTITUENTS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM ISOTOPES; GLANDS; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANOIDS; ORGANS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
5825304
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
HEDB
Size:
Pages: 262-268
Announcement Date:

Journal Article:

Citation Formats

Ando, A, Ando, I, Sanada, S, Hiraki, T, and Hisada, K. Tumor and liver uptake models of /sup 67/Ga-citrate. Germany: N. p., 1985. Web.
Ando, A, Ando, I, Sanada, S, Hiraki, T, & Hisada, K. Tumor and liver uptake models of /sup 67/Ga-citrate. Germany.
Ando, A, Ando, I, Sanada, S, Hiraki, T, and Hisada, K. 1985. "Tumor and liver uptake models of /sup 67/Ga-citrate." Germany.
@misc{etde_5825304,
title = {Tumor and liver uptake models of /sup 67/Ga-citrate}
author = {Ando, A, Ando, I, Sanada, S, Hiraki, T, and Hisada, K}
abstractNote = {After administration /sup 67/Ga concentrates with time in lysosomes from the cytoplasm of liver cells. The lysosomal role in the accumulation of /sup 67/Ga in the liver cell is weakened upon transformation of the liver cell into a malignant tumor cell. In malignant tumors (except for hepatoma) the lysosome does not play a major role in the tumor concentration of /sup 67/Ga. /sup 67/Ga is bound to acid mucopolysaccharides (keratan polysulfate, etc.) in both tumor and liver. In liver cells, large amounts of /sup 67/Ga are transported into lysosomes with these acid mucopolysaccharides, and in hepatoma cells, quite large amounts of /sup 67/Ga are transported into lysosomes with these acid mucopolysaccharides. In malignant tumor cells (except for hepatoma) the effect is much smaller, the acid mucopolysaccharides transporting very little /sup 67/Ga into lysosome. The /sup 67/Ga is concentrated in viable tumor tissue within malignant tissue but hardly at all in necrotic tumor tissue, and concentrates avidly in inflammatory infiltration around tumor cells. Plenty of /sup 67/Ga is found in liver but very little in connective tissue associated with the liver.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {10:5/6}
journal type = {AC}
place = {Germany}
year = {1985}
month = {Mar}
}