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In-vivo determination of total body water and lean body mass in subjects by deuterium dilution

Journal Article:

Abstract

Total body water (TBW) estimation is one of a number of basic techniques required for the determination of body composition in normal and malnourished subjects. When combined with total body nitrogen (TBN) analysis by prompt gamma neutron activation, an accurate compartmental model of in vivo body composition can be formed, providing valuable nutritional and other data. This study examines the role of TBW on its own in evaluating lean body mass. Total body water was studied in six male and five female subjects using deuterium oxide and a Fourier transform infrared spectrometer. The lean body mass calculated from the results was compared with the lean body mass deduced from established total body nitrogen measurements. A four-compartment model was also used to calculate lean body mass. Excellent agreement was shown between lean body mass derived from TBW, the four-compartment model and TBN. Hence, TBW can provide a fast, cost-efficient method for evaluating normal subjects. However, for disease-induced malnutrition, or highly developed athletes, both TBN and TBW measurements are essential to establish an accurate picture of their body composition. TBW measurements alone can monitor the hydration state of patients and as such have a useful diagnostic value.
Publication Date:
Dec 01, 1988
Product Type:
Journal Article
Reference Number:
AIX-20-068923; EDB-89-138293
Resource Relation:
Journal Name: Newsl. Aust. N.Z. Soc. Nucl. Med.; (Australia); Journal Volume: 19:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BODY COMPOSITION; HEAVY WATER; BLOOD PLASMA; DEUTERIUM; FOURIER TRANSFORMATION; INFRARED SPECTRA; ISOTOPE DILUTION; NITROGEN; NUTRITION; RADIONUCLIDE KINETICS; URINE; WATER; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY FLUIDS; ELEMENTS; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; INTEGRAL TRANSFORMATIONS; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MATERIALS; NONMETALS; NUCLEI; ODD-ODD NUCLEI; OXYGEN COMPOUNDS; SPECTRA; STABLE ISOTOPES; TRACER TECHNIQUES; TRANSFORMATIONS; WASTES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5821892
Research Organizations:
Australian Nuclear Science and Technology Organisation, Lucas Heights (Australia); Royal Alexandria Hospital for Children, Camperdown NSW (Australia)
Country of Origin:
Australia
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NANMD
Submitting Site:
INIS
Size:
Pages: 14-16
Announcement Date:
Apr 01, 1989

Journal Article:

Citation Formats

Blagojevic, N, Allen, B J, Baur, L, and Gaskin, K. In-vivo determination of total body water and lean body mass in subjects by deuterium dilution. Australia: N. p., 1988. Web.
Blagojevic, N, Allen, B J, Baur, L, & Gaskin, K. In-vivo determination of total body water and lean body mass in subjects by deuterium dilution. Australia.
Blagojevic, N, Allen, B J, Baur, L, and Gaskin, K. 1988. "In-vivo determination of total body water and lean body mass in subjects by deuterium dilution." Australia.
@misc{etde_5821892,
title = {In-vivo determination of total body water and lean body mass in subjects by deuterium dilution}
author = {Blagojevic, N, Allen, B J, Baur, L, and Gaskin, K}
abstractNote = {Total body water (TBW) estimation is one of a number of basic techniques required for the determination of body composition in normal and malnourished subjects. When combined with total body nitrogen (TBN) analysis by prompt gamma neutron activation, an accurate compartmental model of in vivo body composition can be formed, providing valuable nutritional and other data. This study examines the role of TBW on its own in evaluating lean body mass. Total body water was studied in six male and five female subjects using deuterium oxide and a Fourier transform infrared spectrometer. The lean body mass calculated from the results was compared with the lean body mass deduced from established total body nitrogen measurements. A four-compartment model was also used to calculate lean body mass. Excellent agreement was shown between lean body mass derived from TBW, the four-compartment model and TBN. Hence, TBW can provide a fast, cost-efficient method for evaluating normal subjects. However, for disease-induced malnutrition, or highly developed athletes, both TBN and TBW measurements are essential to establish an accurate picture of their body composition. TBW measurements alone can monitor the hydration state of patients and as such have a useful diagnostic value.}
journal = {Newsl. Aust. N.Z. Soc. Nucl. Med.; (Australia)}
volume = {19:4}
journal type = {AC}
place = {Australia}
year = {1988}
month = {Dec}
}