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Dementia syndrome and the onset of mind

Journal Article:

Abstract

The present report is designed to make clear the mechanism of dementia syndrome and the onset area of the mind. The plan of the statistic studies with X-CT, MRI and PET to find out the focus of dementia in the cortex was an absolute failure. A large number of patients having infarction of varying numbers and sizes in the cortex was neuropsychologically normal. With MRI, quantitative changes of atrophy and destruction were observed in the amygdaloid and hippocampal system bilaterally in both multiinfarct dementia (MID) and Alzheimer disease (AD) patients. With PET, the activity or excitability of the cortices was estimated by measuring the glucose utilization with /sup 18/F-2-fluorodeoxyglucose in response to musical stimulation (a Japanese popular song entitled Sakura, Sakura=cherry blossoms, cherry blossoms) while having the eyes closed, (1) Not only normal volunteers but also with cases of MID and AD, the primary sensory and motor areas were stimulated. (2) In cases of MID and AD, the glucose utilization, was reduced drastically in the bilateral temporal and parietal association cortices. The impulses from all the primary sensory areas drain into the amygdala. Furthermore the impulses from the amygdala drain directly or indirectly into the hippocampus, and the impulses flow  More>>
Publication Date:
Dec 01, 1988
Product Type:
Journal Article
Reference Number:
JPN-89-011367; EDB-89-138316
Resource Relation:
Journal Name: Sci. Rep. Res. Inst., Tohoku Univ., Ser. C; (Japan); Journal Volume: 35:1-4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRAL CORTEX; NMR IMAGING; POSITRON COMPUTED TOMOGRAPHY; FLUORINE 18; ATROPHY; CAT SCANNING; GLUCOSE; HIPPOCAMPUS; MENTAL DISORDERS; METABOLISM; PATIENTS; REFERENCE MAN; SIZE; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; CEREBRUM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; SACCHARIDES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5821814
Research Organizations:
Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis and Cancer
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: SRTCA
Submitting Site:
JPN
Size:
Pages: 29-34
Announcement Date:
Apr 01, 1989

Journal Article:

Citation Formats

Matsuzawa, Taiju, Meguro, Kenichi, Ueda, Masamichi, and Matsui, Hiroshige. Dementia syndrome and the onset of mind. Japan: N. p., 1988. Web.
Matsuzawa, Taiju, Meguro, Kenichi, Ueda, Masamichi, & Matsui, Hiroshige. Dementia syndrome and the onset of mind. Japan.
Matsuzawa, Taiju, Meguro, Kenichi, Ueda, Masamichi, and Matsui, Hiroshige. 1988. "Dementia syndrome and the onset of mind." Japan.
@misc{etde_5821814,
title = {Dementia syndrome and the onset of mind}
author = {Matsuzawa, Taiju, Meguro, Kenichi, Ueda, Masamichi, and Matsui, Hiroshige}
abstractNote = {The present report is designed to make clear the mechanism of dementia syndrome and the onset area of the mind. The plan of the statistic studies with X-CT, MRI and PET to find out the focus of dementia in the cortex was an absolute failure. A large number of patients having infarction of varying numbers and sizes in the cortex was neuropsychologically normal. With MRI, quantitative changes of atrophy and destruction were observed in the amygdaloid and hippocampal system bilaterally in both multiinfarct dementia (MID) and Alzheimer disease (AD) patients. With PET, the activity or excitability of the cortices was estimated by measuring the glucose utilization with /sup 18/F-2-fluorodeoxyglucose in response to musical stimulation (a Japanese popular song entitled Sakura, Sakura=cherry blossoms, cherry blossoms) while having the eyes closed, (1) Not only normal volunteers but also with cases of MID and AD, the primary sensory and motor areas were stimulated. (2) In cases of MID and AD, the glucose utilization, was reduced drastically in the bilateral temporal and parietal association cortices. The impulses from all the primary sensory areas drain into the amygdala. Furthermore the impulses from the amygdala drain directly or indirectly into the hippocampus, and the impulses flow into the temporal cortex. Recognition may take place in this temporal cortex. Then, the impulses come to the parietal cortex. Conception may be completed there. Any damage to the amygdaloid and hippocampal system would result in abnormalities in memory, recognition, conception and various emotions. This is a possible mechanism of dementia syndrome. In view of this data the system also can be said to be the onset area of the mind. (author).}
journal = {Sci. Rep. Res. Inst., Tohoku Univ., Ser. C; (Japan)}
volume = {35:1-4}
journal type = {AC}
place = {Japan}
year = {1988}
month = {Dec}
}