Abstract
Cranial computed tomography scans were performed on 47 patients with systemic lupus erythematosus (SLE). Abnormal findings in the computed tomograms (CT) were observed in 17 patients (36.2%). Cerebral atrophy was the most common feature (eight cases), followed by abnormal high density areas (five cases), abnormal low density areas (three cases), sulcal enlargement (two cases), intracranial hemorrhage (one case) and others (two cases). The abnormal cranial CT group of SLE was associated with a significantly higher incidence of urinary casts and of thrombocytopenia. In particular, the frequency of urinary casts was greater in the group with cerebral atrophy than in the group with normal CT findings, and there was a higher incidence of alopecia, leukopenia and thrombocytopenia in the group with intracranial calcifications. Neuropsychiatric involvements were noted in 70.6% of patients with CT abnormalities, but neuropsychiatric features (20.7%) and electroencephalographic abnormalities (44.8%) were also observed in patients with normal CT findings. The age at onset of SLE, the mean duration of the disease and the survival rate were not significantly different between the groups with and without CT abnormalities, but the mortality rate was significantly greater in the group with CT abnormalities, especially among those with brain atrophy. Concerning the relationship
More>>
Nagaoka, S;
Ishigatsubo, Y;
Katou, K;
Sakamoto, H;
Chiba, J
[1]
- Yokohama City Univ. (Japan). Faculty of Medicine
Citation Formats
Nagaoka, S, Ishigatsubo, Y, Katou, K, Sakamoto, H, and Chiba, J.
Central nervous system involvement in systemic lupus erythematosus. The application of cranial computed tomography.
Japan: N. p.,
1982.
Web.
Nagaoka, S, Ishigatsubo, Y, Katou, K, Sakamoto, H, & Chiba, J.
Central nervous system involvement in systemic lupus erythematosus. The application of cranial computed tomography.
Japan.
Nagaoka, S, Ishigatsubo, Y, Katou, K, Sakamoto, H, and Chiba, J.
1982.
"Central nervous system involvement in systemic lupus erythematosus. The application of cranial computed tomography."
Japan.
@misc{etde_5819599,
title = {Central nervous system involvement in systemic lupus erythematosus. The application of cranial computed tomography}
author = {Nagaoka, S, Ishigatsubo, Y, Katou, K, Sakamoto, H, and Chiba, J}
abstractNote = {Cranial computed tomography scans were performed on 47 patients with systemic lupus erythematosus (SLE). Abnormal findings in the computed tomograms (CT) were observed in 17 patients (36.2%). Cerebral atrophy was the most common feature (eight cases), followed by abnormal high density areas (five cases), abnormal low density areas (three cases), sulcal enlargement (two cases), intracranial hemorrhage (one case) and others (two cases). The abnormal cranial CT group of SLE was associated with a significantly higher incidence of urinary casts and of thrombocytopenia. In particular, the frequency of urinary casts was greater in the group with cerebral atrophy than in the group with normal CT findings, and there was a higher incidence of alopecia, leukopenia and thrombocytopenia in the group with intracranial calcifications. Neuropsychiatric involvements were noted in 70.6% of patients with CT abnormalities, but neuropsychiatric features (20.7%) and electroencephalographic abnormalities (44.8%) were also observed in patients with normal CT findings. The age at onset of SLE, the mean duration of the disease and the survival rate were not significantly different between the groups with and without CT abnormalities, but the mortality rate was significantly greater in the group with CT abnormalities, especially among those with brain atrophy. Concerning the relationship between the findings of cranial CT and corticosteroid treatment, there was no significant difference in either the total dose or the mean duration of prednisolone therapy. Although SLE patients with cerebral atrophy were taking a larger maintenance dose of corticosteroids, the differences were not statistically significant.}
journal = []
volume = {22:3}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Jun}
}
title = {Central nervous system involvement in systemic lupus erythematosus. The application of cranial computed tomography}
author = {Nagaoka, S, Ishigatsubo, Y, Katou, K, Sakamoto, H, and Chiba, J}
abstractNote = {Cranial computed tomography scans were performed on 47 patients with systemic lupus erythematosus (SLE). Abnormal findings in the computed tomograms (CT) were observed in 17 patients (36.2%). Cerebral atrophy was the most common feature (eight cases), followed by abnormal high density areas (five cases), abnormal low density areas (three cases), sulcal enlargement (two cases), intracranial hemorrhage (one case) and others (two cases). The abnormal cranial CT group of SLE was associated with a significantly higher incidence of urinary casts and of thrombocytopenia. In particular, the frequency of urinary casts was greater in the group with cerebral atrophy than in the group with normal CT findings, and there was a higher incidence of alopecia, leukopenia and thrombocytopenia in the group with intracranial calcifications. Neuropsychiatric involvements were noted in 70.6% of patients with CT abnormalities, but neuropsychiatric features (20.7%) and electroencephalographic abnormalities (44.8%) were also observed in patients with normal CT findings. The age at onset of SLE, the mean duration of the disease and the survival rate were not significantly different between the groups with and without CT abnormalities, but the mortality rate was significantly greater in the group with CT abnormalities, especially among those with brain atrophy. Concerning the relationship between the findings of cranial CT and corticosteroid treatment, there was no significant difference in either the total dose or the mean duration of prednisolone therapy. Although SLE patients with cerebral atrophy were taking a larger maintenance dose of corticosteroids, the differences were not statistically significant.}
journal = []
volume = {22:3}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Jun}
}