You need JavaScript to view this

Determination of bacterial endotoxins in blood of animals and humans subjected to irradiation

Abstract

The content of Gram-negative bacterium endotoxins in the irradiated organism was determined by the use of actinomycin D sensitizing the organism to the effect of such toxins. Regularities in the accumulation of Gram-negative bacterium endotoxins in the irradiated organism were studied as well as the dependence of animal sensitization on the actinomycin D dose. Possibilities for the development of endotoxemia in oncologic patients in the process of radiotheraphy were traced. It is shown that the radiotherapy of the intestine containing large quantaties of bacteria and their toxins is accompanied by endotoxemia; in the first part of the radiotherapy course its manifestation depends on the irradiation dose; having reached a specific level, endotoxemia retains its symptoms till the end of irradiation. It is indicated that the determination of bacterium endotoxins is of interest when studying not only the development of endotoxemia in the organism exposed to radiation, hut also many other toxemic states.
Authors:
Kiselev, P N; Shchul's, T S [1] 
  1. Tsentral'nyj Nauchno-Issledovatel'skij Rentgeno-Radiologicheskij Inst., Leningrad (USSR)
Publication Date:
Jan 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-14-776410; EDB-83-179965
Resource Relation:
Journal Name: Lab. Delo; (USSR); Journal Volume: 9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD; ENDOTOXINS; RADIOTHERAPY; SIDE EFFECTS; ACTINOMYCIN; ANIMALS; BACTERIA; DOSE-RESPONSE RELATIONSHIPS; PATIENTS; QUANTITATIVE CHEMICAL ANALYSIS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIGENS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BIOLOGICAL MATERIALS; BODY FLUIDS; CHEMICAL ANALYSIS; DRUGS; MATERIALS; MEDICINE; MICROORGANISMS; NUCLEAR MEDICINE; RADIOLOGY; THERAPY; TOXIC MATERIALS; TOXINS; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man
OSTI ID:
5817115
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: LABDA
Submitting Site:
HEDB
Size:
Pages: 561-563
Announcement Date:
Aug 01, 1983

Citation Formats

Kiselev, P N, and Shchul's, T S. Determination of bacterial endotoxins in blood of animals and humans subjected to irradiation. USSR: N. p., 1981. Web.
Kiselev, P N, & Shchul's, T S. Determination of bacterial endotoxins in blood of animals and humans subjected to irradiation. USSR.
Kiselev, P N, and Shchul's, T S. 1981. "Determination of bacterial endotoxins in blood of animals and humans subjected to irradiation." USSR.
@misc{etde_5817115,
title = {Determination of bacterial endotoxins in blood of animals and humans subjected to irradiation}
author = {Kiselev, P N, and Shchul's, T S}
abstractNote = {The content of Gram-negative bacterium endotoxins in the irradiated organism was determined by the use of actinomycin D sensitizing the organism to the effect of such toxins. Regularities in the accumulation of Gram-negative bacterium endotoxins in the irradiated organism were studied as well as the dependence of animal sensitization on the actinomycin D dose. Possibilities for the development of endotoxemia in oncologic patients in the process of radiotheraphy were traced. It is shown that the radiotherapy of the intestine containing large quantaties of bacteria and their toxins is accompanied by endotoxemia; in the first part of the radiotherapy course its manifestation depends on the irradiation dose; having reached a specific level, endotoxemia retains its symptoms till the end of irradiation. It is indicated that the determination of bacterium endotoxins is of interest when studying not only the development of endotoxemia in the organism exposed to radiation, hut also many other toxemic states.}
journal = []
volume = {9}
journal type = {AC}
place = {USSR}
year = {1981}
month = {Jan}
}