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Urinary excretion of creatine and creatinine in gamma irradiated rats

Journal Article:

Abstract

Dose response relationships of creatine, creatinine excretions and their ratio in 24 hr urine samples have been studied on each individual day upto 4 days after 1-7 Gy whole body gamma irradiation to rats. Creatine excretion reaches the peak on the 2nd day while creatinine excretion reaches the peak on the first day and a plateau is maintained up to the 4th day in each case. Good dose response correlationship is maintained for creatine or creatinine levels up to the 4th day and for creatine creatinine ratio up to the 3rd day. Seperate dose response curves are needed on each individual day for using these parameters for biological dosimetry purpose. Administration of the radioprotectors viz., combination of 5-hydroxytryptophan (HT) and 2-amino-ethylisothiuronium bromide hydrobromide (AET), HT alone and optimum radioprotecting dose of AET before 5 Gy whole body ..gamma..-irradiation have not been of help for reducing creatinineurea. (author).
Publication Date:
Jun 01, 1985
Product Type:
Journal Article
Reference Number:
EDB-86-111939
Resource Relation:
Journal Name: J. Radiat. Res.; (Japan); Journal Volume: 26:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; METABOLISM; BIOLOGICAL RADIATION EFFECTS; RADIOPROTECTIVE SUBSTANCES; RADIOSENSITIVITY EFFECTS; RATS; WHOLE-BODY IRRADIATION; AET; CREATINE; CREATININE; DOSE-RESPONSE RELATIONSHIPS; EXCRETION; GAMMA RADIATION; HYDROXYTRYPTOPHAN; TIME DEPENDENCE; URINE; AMINES; AMINO ACIDS; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; CLEARANCE; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY ACIDS; IMIDAZOLES; IMINES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MATERIALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; THIOUREAS; VERTEBRATES; WASTES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5802442
Research Organizations:
Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JRARA
Submitting Site:
INIS
Size:
Pages: 189-195
Announcement Date:

Journal Article:

Citation Formats

Basu, S K, Srinivasan, M N, Chuttani, K, Bhatnagar, A, and Ghose, A. Urinary excretion of creatine and creatinine in gamma irradiated rats. Japan: N. p., 1985. Web.
Basu, S K, Srinivasan, M N, Chuttani, K, Bhatnagar, A, & Ghose, A. Urinary excretion of creatine and creatinine in gamma irradiated rats. Japan.
Basu, S K, Srinivasan, M N, Chuttani, K, Bhatnagar, A, and Ghose, A. 1985. "Urinary excretion of creatine and creatinine in gamma irradiated rats." Japan.
@misc{etde_5802442,
title = {Urinary excretion of creatine and creatinine in gamma irradiated rats}
author = {Basu, S K, Srinivasan, M N, Chuttani, K, Bhatnagar, A, and Ghose, A}
abstractNote = {Dose response relationships of creatine, creatinine excretions and their ratio in 24 hr urine samples have been studied on each individual day upto 4 days after 1-7 Gy whole body gamma irradiation to rats. Creatine excretion reaches the peak on the 2nd day while creatinine excretion reaches the peak on the first day and a plateau is maintained up to the 4th day in each case. Good dose response correlationship is maintained for creatine or creatinine levels up to the 4th day and for creatine creatinine ratio up to the 3rd day. Seperate dose response curves are needed on each individual day for using these parameters for biological dosimetry purpose. Administration of the radioprotectors viz., combination of 5-hydroxytryptophan (HT) and 2-amino-ethylisothiuronium bromide hydrobromide (AET), HT alone and optimum radioprotecting dose of AET before 5 Gy whole body ..gamma..-irradiation have not been of help for reducing creatinineurea. (author).}
journal = {J. Radiat. Res.; (Japan)}
volume = {26:2}
journal type = {AC}
place = {Japan}
year = {1985}
month = {Jun}
}