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Role of leucine in isoprenoid metabolism. Incorporation of (3-/sup 13/C)leucine and of (2-/sup 3/H,4-/sup 14/C)-. beta. ,. beta. -dimethyl-acrylic acid into phytosterols by tissue cultures of Andrographis paniculata

Journal Article:

Abstract

(3-/sup 13/C)Leucine is incorporated into phytosterols by tissue cultures of Andrographis paniculata by breakdown to acetyl-CoA and its subsequent incorporation via (3S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and mevalonic acid; (2-/sup 3/H,4-/sup 14/C)-..beta..,..beta..-dimethylacrylic acid also is not incorporated intact.
Authors:
Anastasis, P; Freer, I; Overton, K; Rycroft, D; Singh, S B [1] 
  1. Glasgow Univ. (UK). Dept. of Chemistry
Publication Date:
Feb 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-16-033613; EDB-85-096020
Resource Relation:
Journal Name: J. Chem. Soc., Chem. Commun.; (United Kingdom); Journal Volume: 3
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CARBON 13; ISOTOPIC EXCHANGE; STEROLS; LABELLING; TRITIUM; BIOSYNTHESIS; CARBON 14; CATABOLISM; LABELLED COMPOUNDS; LEUCINE; MICROORGANISMS; MONOCARBOXYLIC ACIDS; TISSUE CULTURES; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; METABOLISM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; STABLE ISOTOPES; STEROIDS; SYNTHESIS; YEARS LIVING RADIOISOTOPES; 400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production; 400303 - Organic Chemistry- Isotope Exchange & Isotope Separation- (-1987)
OSTI ID:
5785083
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JCCCA
Submitting Site:
HEDB
Size:
Pages: 148-149
Announcement Date:
May 01, 1985

Journal Article:

Citation Formats

Anastasis, P, Freer, I, Overton, K, Rycroft, D, and Singh, S B. Role of leucine in isoprenoid metabolism. Incorporation of (3-/sup 13/C)leucine and of (2-/sup 3/H,4-/sup 14/C)-. beta. ,. beta. -dimethyl-acrylic acid into phytosterols by tissue cultures of Andrographis paniculata. United Kingdom: N. p., 1985. Web.
Anastasis, P, Freer, I, Overton, K, Rycroft, D, & Singh, S B. Role of leucine in isoprenoid metabolism. Incorporation of (3-/sup 13/C)leucine and of (2-/sup 3/H,4-/sup 14/C)-. beta. ,. beta. -dimethyl-acrylic acid into phytosterols by tissue cultures of Andrographis paniculata. United Kingdom.
Anastasis, P, Freer, I, Overton, K, Rycroft, D, and Singh, S B. 1985. "Role of leucine in isoprenoid metabolism. Incorporation of (3-/sup 13/C)leucine and of (2-/sup 3/H,4-/sup 14/C)-. beta. ,. beta. -dimethyl-acrylic acid into phytosterols by tissue cultures of Andrographis paniculata." United Kingdom.
@misc{etde_5785083,
title = {Role of leucine in isoprenoid metabolism. Incorporation of (3-/sup 13/C)leucine and of (2-/sup 3/H,4-/sup 14/C)-. beta. ,. beta. -dimethyl-acrylic acid into phytosterols by tissue cultures of Andrographis paniculata}
author = {Anastasis, P, Freer, I, Overton, K, Rycroft, D, and Singh, S B}
abstractNote = {(3-/sup 13/C)Leucine is incorporated into phytosterols by tissue cultures of Andrographis paniculata by breakdown to acetyl-CoA and its subsequent incorporation via (3S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and mevalonic acid; (2-/sup 3/H,4-/sup 14/C)-..beta..,..beta..-dimethylacrylic acid also is not incorporated intact.}
journal = {J. Chem. Soc., Chem. Commun.; (United Kingdom)}
volume = {3}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Feb}
}