You need JavaScript to view this

Assessment of specific IgM antibodies to core antigen of hepatitis B virus in acute and chronic hepatitis B using immunoradiometric assay

Journal Article:

Abstract

A group of 24 patients with acute viral hepatitis B was assessed for specific antibodies against the ''core'' antigen class IgM (HB/sub c/AB IgM) during 1st-4th week of the illness. These specific antibodies were positive in all patients, the mean titre being 10/sup -5/. The high content of these antibodies persisted for 1-2 months after the onset of the disease. The assessment of specific antibodies against ''core'' antigen class IgM was also made in a group of 39 patients with chronic hepatitis. In these patients positive HB/sub c/Ab IgM with a lower content were found (titre 10/sup -3/) than in the group with acute viral hepatitis B. Based on the results the conclusion is made that specific antibodies HB/sub c/Ab class IgM are, in addition to the estimation of the surface antigen of the hepatitis B virus (HB/sub s/Ag), one more indicator of acute viral hepatitis B. The assessment is diagnostically valuable, in particular in acute hepatitis of obscure etiology, in acute jaundice of obscure etiology for the period of low and short-term antigenemia. (author). 6 figs., 1 tab., 14 refs.
Publication Date:
Dec 31, 1986
Product Type:
Journal Article
Reference Number:
AIX-19-013116; EDB-88-031033
Resource Relation:
Journal Name: Cas. Lek. Cesk.; (Czechoslovakia); Journal Volume: 128:52; Other Information: English translation available from Nuclear Information Center, 156 16 Prague 5-Zbraslav, Czechoslovakia at US$ 10 per page
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; HEPATITIS; RADIOIMMUNOASSAY; ANTIGENS; IMMUNOGLOBULINS; IODINE 125; VIRAL DISEASES; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM DISEASES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; IMMUNOASSAY; IMMUNOLOGY; INFECTIOUS DISEASES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5781639
Research Organizations:
Ustredni Vojenska Nemocnice, Prague, Czechoslovakia
Country of Origin:
Serbia and Montenegro
Language:
Czech
Other Identifying Numbers:
Journal ID: CODEN: CLCEA
Submitting Site:
INIS
Size:
Pages: 1604-1607
Announcement Date:

Journal Article:

Citation Formats

Zichova, M, Vodak, M, Kostrhun, L, Nadvornik, V, and Stransky, J. Assessment of specific IgM antibodies to core antigen of hepatitis B virus in acute and chronic hepatitis B using immunoradiometric assay. Serbia and Montenegro: N. p., 1986. Web.
Zichova, M, Vodak, M, Kostrhun, L, Nadvornik, V, & Stransky, J. Assessment of specific IgM antibodies to core antigen of hepatitis B virus in acute and chronic hepatitis B using immunoradiometric assay. Serbia and Montenegro.
Zichova, M, Vodak, M, Kostrhun, L, Nadvornik, V, and Stransky, J. 1986. "Assessment of specific IgM antibodies to core antigen of hepatitis B virus in acute and chronic hepatitis B using immunoradiometric assay." Serbia and Montenegro.
@misc{etde_5781639,
title = {Assessment of specific IgM antibodies to core antigen of hepatitis B virus in acute and chronic hepatitis B using immunoradiometric assay}
author = {Zichova, M, Vodak, M, Kostrhun, L, Nadvornik, V, and Stransky, J}
abstractNote = {A group of 24 patients with acute viral hepatitis B was assessed for specific antibodies against the ''core'' antigen class IgM (HB/sub c/AB IgM) during 1st-4th week of the illness. These specific antibodies were positive in all patients, the mean titre being 10/sup -5/. The high content of these antibodies persisted for 1-2 months after the onset of the disease. The assessment of specific antibodies against ''core'' antigen class IgM was also made in a group of 39 patients with chronic hepatitis. In these patients positive HB/sub c/Ab IgM with a lower content were found (titre 10/sup -3/) than in the group with acute viral hepatitis B. Based on the results the conclusion is made that specific antibodies HB/sub c/Ab class IgM are, in addition to the estimation of the surface antigen of the hepatitis B virus (HB/sub s/Ag), one more indicator of acute viral hepatitis B. The assessment is diagnostically valuable, in particular in acute hepatitis of obscure etiology, in acute jaundice of obscure etiology for the period of low and short-term antigenemia. (author). 6 figs., 1 tab., 14 refs.}
journal = {Cas. Lek. Cesk.; (Czechoslovakia)}
volume = {128:52}
journal type = {AC}
place = {Serbia and Montenegro}
year = {1986}
month = {Dec}
}