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Transformation from refractory anemia with excess of blasts (RAEB) into acute myeloid leukemia (AML) obserbed in a heavily exposed atomic bomb survivor

Journal Article:

Abstract

A heavily exposed atomic bomb survivor, 59-year-old man presented refractory anemia with excess of blasts (RAEB) terminating in acute myeloid leukemia (AML) 38 years after exposure. When he manifested AML, combination chemotherapy was started. But complete remission was not obtained even by B-DOMP regimen. Cytogenetic studies were performed, and their relation to the clinical course was analyzed. Peripheral blood T lymphocytes had 41.9 % non-clonal chromosomal abnormalities suggesting over 400 rad exposure. Bone marrow cells at RAEB exhibited a presence of mosaic clones of normal and abnormal chromosomal pattern, which supported the clinical diagnosis of RAEB and corresponded to the clinical features such as steady state and a low percentage of myeloblasts. At transformation into AML, clonal chromosomal abnormality was seen in bone marrow cells. It may explain a rapid increase of abnormal cells. This abnormal clone showed a little different karyotype seen at RAEB. But it was suspected to derive from a clone at RAEB, because of the same persistent chromosomal abnormalities. Then it aquired an additional chromosomal abnormalities at clinically drug-resistant phase of AML. In vivo selection assay of these leukemic cells revealed that transforming gene took part in this leukemogenesis. These data shown in this paper contribute  More>>
Publication Date:
Jan 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-88-061175; EDB-88-031811
Resource Relation:
Journal Name: Hiroshima Daigaku Genbaku Hoshano Igaku Kenkyusho Nenpo; (Japan); Journal Volume: 28
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; LEUKEMOGENESIS; ANEMIAS; BONE MARROW CELLS; CHEMOTHERAPY; CHROMOSOMAL ABERRATIONS; CLONE CELLS; DELAYED RADIATION EFFECTS; LYMPHOCYTES; MYELOID LEUKEMIA; ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARCINOGENESIS; CELL CULTURES; CONNECTIVE TISSUE CELLS; DISEASES; HEMIC DISEASES; HUMAN POPULATIONS; LEUKEMIA; LEUKOCYTES; MATERIALS; MUTATIONS; NEOPLASMS; PATHOGENESIS; POPULATIONS; RADIATION EFFECTS; SOMATIC CELLS; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5778745
Research Organizations:
Hiroshima Univ., Japan. Research Inst. for Nuclear Medicine and Biology
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HDGHA
Submitting Site:
JPN
Size:
Pages: 341-347
Announcement Date:

Journal Article:

Citation Formats

Iwato, Koji, Kawano, Michio, Kimura, Akiro, Kuramoto, Atsushi, Tanaka, Kimio, and Kamada, Nanao. Transformation from refractory anemia with excess of blasts (RAEB) into acute myeloid leukemia (AML) obserbed in a heavily exposed atomic bomb survivor. Japan: N. p., 1987. Web.
Iwato, Koji, Kawano, Michio, Kimura, Akiro, Kuramoto, Atsushi, Tanaka, Kimio, & Kamada, Nanao. Transformation from refractory anemia with excess of blasts (RAEB) into acute myeloid leukemia (AML) obserbed in a heavily exposed atomic bomb survivor. Japan.
Iwato, Koji, Kawano, Michio, Kimura, Akiro, Kuramoto, Atsushi, Tanaka, Kimio, and Kamada, Nanao. 1987. "Transformation from refractory anemia with excess of blasts (RAEB) into acute myeloid leukemia (AML) obserbed in a heavily exposed atomic bomb survivor." Japan.
@misc{etde_5778745,
title = {Transformation from refractory anemia with excess of blasts (RAEB) into acute myeloid leukemia (AML) obserbed in a heavily exposed atomic bomb survivor}
author = {Iwato, Koji, Kawano, Michio, Kimura, Akiro, Kuramoto, Atsushi, Tanaka, Kimio, and Kamada, Nanao}
abstractNote = {A heavily exposed atomic bomb survivor, 59-year-old man presented refractory anemia with excess of blasts (RAEB) terminating in acute myeloid leukemia (AML) 38 years after exposure. When he manifested AML, combination chemotherapy was started. But complete remission was not obtained even by B-DOMP regimen. Cytogenetic studies were performed, and their relation to the clinical course was analyzed. Peripheral blood T lymphocytes had 41.9 % non-clonal chromosomal abnormalities suggesting over 400 rad exposure. Bone marrow cells at RAEB exhibited a presence of mosaic clones of normal and abnormal chromosomal pattern, which supported the clinical diagnosis of RAEB and corresponded to the clinical features such as steady state and a low percentage of myeloblasts. At transformation into AML, clonal chromosomal abnormality was seen in bone marrow cells. It may explain a rapid increase of abnormal cells. This abnormal clone showed a little different karyotype seen at RAEB. But it was suspected to derive from a clone at RAEB, because of the same persistent chromosomal abnormalities. Then it aquired an additional chromosomal abnormalities at clinically drug-resistant phase of AML. In vivo selection assay of these leukemic cells revealed that transforming gene took part in this leukemogenesis. These data shown in this paper contribute to investigate a mechanism of leukemogenesis in atomic bomb survivors and establishment of new therapy.}
journal = {Hiroshima Daigaku Genbaku Hoshano Igaku Kenkyusho Nenpo; (Japan)}
volume = {28}
journal type = {AC}
place = {Japan}
year = {1987}
month = {Jan}
}