You need JavaScript to view this

Critical appraisal of semi-quantitative analysis of 2-deoxyglucose autoradiograms

Journal Article:

Abstract

Semi-quantitative analysis (e.g. optical density ratios) of (/sup 14/C)2-deoxyglucose autoradiograms is widely used in neuroscience research. The authors demonstrate that a fixed ratio of /sup 14/C-concentrations in the CNS does not yield a constant optical density ratio but is dependent upon the exposure time in the preparation of the autoradiograms and the absolute amounts of /sup 14/C from which the concentration ratio is derived. The failure of a fixed glucose utilization ratio to result in a constant optical density ratio represents a major interpretative difficulty in investigations where only semi-quantitative analysis of (/sup 14/C)2-deoxyglucose autoradiograms is undertaken.
Authors:
Kelly, P T; McCulloch, J [1] 
  1. Glasgow Univ. (UK)
Publication Date:
Jun 13, 1983
Product Type:
Journal Article
Reference Number:
AIX-14-792750; EDB-83-188366
Resource Relation:
Journal Name: Brain Res.; (Netherlands); Journal Volume: 269:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AUTORADIOGRAPHY; ACCURACY; CARBON 14; DIAGNOSTIC USES; CENTRAL NERVOUS SYSTEM; CARBON 14 COMPOUNDS; GLUCOSE; OPACITY; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOHYDRATES; CARBON ISOTOPES; EVEN-EVEN NUCLEI; HEXOSES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; OPTICAL PROPERTIES; ORGANIC COMPOUNDS; PHYSICAL PROPERTIES; RADIOISOTOPES; SACCHARIDES; USES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5776308
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BRREA
Submitting Site:
HEDB
Size:
Pages: 165-167
Announcement Date:
Sep 01, 1983

Journal Article:

Citation Formats

Kelly, P T, and McCulloch, J. Critical appraisal of semi-quantitative analysis of 2-deoxyglucose autoradiograms. Netherlands: N. p., 1983. Web.
Kelly, P T, & McCulloch, J. Critical appraisal of semi-quantitative analysis of 2-deoxyglucose autoradiograms. Netherlands.
Kelly, P T, and McCulloch, J. 1983. "Critical appraisal of semi-quantitative analysis of 2-deoxyglucose autoradiograms." Netherlands.
@misc{etde_5776308,
title = {Critical appraisal of semi-quantitative analysis of 2-deoxyglucose autoradiograms}
author = {Kelly, P T, and McCulloch, J}
abstractNote = {Semi-quantitative analysis (e.g. optical density ratios) of (/sup 14/C)2-deoxyglucose autoradiograms is widely used in neuroscience research. The authors demonstrate that a fixed ratio of /sup 14/C-concentrations in the CNS does not yield a constant optical density ratio but is dependent upon the exposure time in the preparation of the autoradiograms and the absolute amounts of /sup 14/C from which the concentration ratio is derived. The failure of a fixed glucose utilization ratio to result in a constant optical density ratio represents a major interpretative difficulty in investigations where only semi-quantitative analysis of (/sup 14/C)2-deoxyglucose autoradiograms is undertaken.}
journal = {Brain Res.; (Netherlands)}
volume = {269:1}
journal type = {AC}
place = {Netherlands}
year = {1983}
month = {Jun}
}