Abstract
Fever of unknown origin (FUO) has been defined as an elevation in temperature (38 C) for at least 2-3 weeks despite intensive investigation. The value of immunoscintigraphy with technetium-99m-labelled anti-granulocyte antibody anti-NCA-95 (BW 250/183, IgGl) was studied retrospectively in 34 consecutive patients with FUO. Every effort was made to confirm a diagnosis, including methods such as ultrasonography, computed tomography, magnetic resonance imaging, bacteriological tests, surgical intervention and clinical follow-up. In 58,8% of the patients, an infectious cause for the fever was found. In 30.2% of the patients, a benign or malignant haematological disease, pancreatitis or thyrotoxicosis was found. No cause for fever could be found in 11%. The overall diagnostic sensitivity and specificity of immunoscintigraphy for infection were 40% and 92% respectively. The positive predictive value was calculated to be 88% and the negative predictive value was calculated to be 52%. False-negative scans were especially noted in patients with endocarditis, pneumonia and small brain abscesses, where the lesions did not exceed a diameter of 0.5 cm. If patients with endocarditis were excluded, the imaging sensitivity and specificity were increased to 57% and 95%. This study demonstrates that 99mTc-anti-NCA-95 scanning is able to localize infectious causes of FUO, other than endocarditis.
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Doelkemeyer, U;
[1]
Gramatzki, M;
[2]
Schneider, M U;
[3]
Scheele, J;
[4]
Wolf, F
[1]
- Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Nuclear Medicine
- Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Medicine 3
- Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Medicine 1
- Erlangen-Nuernberg Univ., Erlangen (Germany). Dept. of Surgery
Citation Formats
Doelkemeyer, U, Gramatzki, M, Schneider, M U, Scheele, J, and Wolf, F.
Use of immunoscintigraphy in the diagnosis of fever of unknown origin.
Germany: N. p.,
1993.
Web.
Doelkemeyer, U, Gramatzki, M, Schneider, M U, Scheele, J, & Wolf, F.
Use of immunoscintigraphy in the diagnosis of fever of unknown origin.
Germany.
Doelkemeyer, U, Gramatzki, M, Schneider, M U, Scheele, J, and Wolf, F.
1993.
"Use of immunoscintigraphy in the diagnosis of fever of unknown origin."
Germany.
@misc{etde_5775071,
title = {Use of immunoscintigraphy in the diagnosis of fever of unknown origin}
author = {Doelkemeyer, U, Gramatzki, M, Schneider, M U, Scheele, J, and Wolf, F}
abstractNote = {Fever of unknown origin (FUO) has been defined as an elevation in temperature (38 C) for at least 2-3 weeks despite intensive investigation. The value of immunoscintigraphy with technetium-99m-labelled anti-granulocyte antibody anti-NCA-95 (BW 250/183, IgGl) was studied retrospectively in 34 consecutive patients with FUO. Every effort was made to confirm a diagnosis, including methods such as ultrasonography, computed tomography, magnetic resonance imaging, bacteriological tests, surgical intervention and clinical follow-up. In 58,8% of the patients, an infectious cause for the fever was found. In 30.2% of the patients, a benign or malignant haematological disease, pancreatitis or thyrotoxicosis was found. No cause for fever could be found in 11%. The overall diagnostic sensitivity and specificity of immunoscintigraphy for infection were 40% and 92% respectively. The positive predictive value was calculated to be 88% and the negative predictive value was calculated to be 52%. False-negative scans were especially noted in patients with endocarditis, pneumonia and small brain abscesses, where the lesions did not exceed a diameter of 0.5 cm. If patients with endocarditis were excluded, the imaging sensitivity and specificity were increased to 57% and 95%. This study demonstrates that 99mTc-anti-NCA-95 scanning is able to localize infectious causes of FUO, other than endocarditis. (orig.)}
journal = []
volume = {20:11}
journal type = {AC}
place = {Germany}
year = {1993}
month = {Nov}
}
title = {Use of immunoscintigraphy in the diagnosis of fever of unknown origin}
author = {Doelkemeyer, U, Gramatzki, M, Schneider, M U, Scheele, J, and Wolf, F}
abstractNote = {Fever of unknown origin (FUO) has been defined as an elevation in temperature (38 C) for at least 2-3 weeks despite intensive investigation. The value of immunoscintigraphy with technetium-99m-labelled anti-granulocyte antibody anti-NCA-95 (BW 250/183, IgGl) was studied retrospectively in 34 consecutive patients with FUO. Every effort was made to confirm a diagnosis, including methods such as ultrasonography, computed tomography, magnetic resonance imaging, bacteriological tests, surgical intervention and clinical follow-up. In 58,8% of the patients, an infectious cause for the fever was found. In 30.2% of the patients, a benign or malignant haematological disease, pancreatitis or thyrotoxicosis was found. No cause for fever could be found in 11%. The overall diagnostic sensitivity and specificity of immunoscintigraphy for infection were 40% and 92% respectively. The positive predictive value was calculated to be 88% and the negative predictive value was calculated to be 52%. False-negative scans were especially noted in patients with endocarditis, pneumonia and small brain abscesses, where the lesions did not exceed a diameter of 0.5 cm. If patients with endocarditis were excluded, the imaging sensitivity and specificity were increased to 57% and 95%. This study demonstrates that 99mTc-anti-NCA-95 scanning is able to localize infectious causes of FUO, other than endocarditis. (orig.)}
journal = []
volume = {20:11}
journal type = {AC}
place = {Germany}
year = {1993}
month = {Nov}
}