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Experimental radioimmunotherapy of a xenografted human glioma using [sup 131]I-labeled monoclonal antibody to epidermal growth factor receptor

Journal Article:

Abstract

[sup 131]I-labeled F (ab')[sub 2] fragments of murine monoclonal antibodies (MAb) 425 specific to the epidermal growth factor receptor expressed on human gliomas were used in experimental human malignant glioma immunotherapy. Two injections of 150 [mu]Ci [sup 131]I-labeled 425 F(ab')[sub 2] achieved growth inhibition of U-87MG human malignant glioma xenografts in nude mice. This radiolabeled specific MAb F(ab')[sub 2] was significantly superior to radiolabeled fragments of an anti-hepatitis virus control MAb A5C3 in influencing tumor growth. However, similar treatment of established human malignant glioma xenografts did not inhibit progressive tumor growth significantly. No clear tumor inhibition was produced by unlabeled MAb 425F(ab')[sub 2]. These studies suggest that [sup 131]I-labeled MAbs have a significant antitumor effect where unmodified antibody is ineffective. Multiple doses of antibody may achieve an increase in labeled MAb concentration in tumors. (author).
Authors:
Takahashi, Hiroshi; Nakazawa, Shozo; [1]  Herlyn, D
  1. Nippon Medical School, Tokyo (Japan)
Publication Date:
Sep 01, 1993
Product Type:
Journal Article
Reference Number:
JPN-93-010327; EDB-93-160722
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 33:9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GLIOMAS; IMMUNOTHERAPY; RADIOTHERAPY; AFFINITY; EPIDERMIS; GRAFTS; GROWTH; IODINE 131; LABELLING; MICE; MONOCLONAL ANTIBODIES; RADIATION DOSES; RECEPTORS; ANIMAL TISSUES; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; DOSES; EPITHELIUM; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; MEDICINE; MEMBRANE PROTEINS; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RADIOLOGY; RODENTS; SKIN; THERAPY; TISSUES; TRANSPLANTS; VERTEBRATES; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
OSTI ID:
5774097
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHBN
Submitting Site:
JPN
Size:
Pages: 610-615
Announcement Date:

Journal Article:

Citation Formats

Takahashi, Hiroshi, Nakazawa, Shozo, and Herlyn, D. Experimental radioimmunotherapy of a xenografted human glioma using [sup 131]I-labeled monoclonal antibody to epidermal growth factor receptor. Japan: N. p., 1993. Web.
Takahashi, Hiroshi, Nakazawa, Shozo, & Herlyn, D. Experimental radioimmunotherapy of a xenografted human glioma using [sup 131]I-labeled monoclonal antibody to epidermal growth factor receptor. Japan.
Takahashi, Hiroshi, Nakazawa, Shozo, and Herlyn, D. 1993. "Experimental radioimmunotherapy of a xenografted human glioma using [sup 131]I-labeled monoclonal antibody to epidermal growth factor receptor." Japan.
@misc{etde_5774097,
title = {Experimental radioimmunotherapy of a xenografted human glioma using [sup 131]I-labeled monoclonal antibody to epidermal growth factor receptor}
author = {Takahashi, Hiroshi, Nakazawa, Shozo, and Herlyn, D}
abstractNote = {[sup 131]I-labeled F (ab')[sub 2] fragments of murine monoclonal antibodies (MAb) 425 specific to the epidermal growth factor receptor expressed on human gliomas were used in experimental human malignant glioma immunotherapy. Two injections of 150 [mu]Ci [sup 131]I-labeled 425 F(ab')[sub 2] achieved growth inhibition of U-87MG human malignant glioma xenografts in nude mice. This radiolabeled specific MAb F(ab')[sub 2] was significantly superior to radiolabeled fragments of an anti-hepatitis virus control MAb A5C3 in influencing tumor growth. However, similar treatment of established human malignant glioma xenografts did not inhibit progressive tumor growth significantly. No clear tumor inhibition was produced by unlabeled MAb 425F(ab')[sub 2]. These studies suggest that [sup 131]I-labeled MAbs have a significant antitumor effect where unmodified antibody is ineffective. Multiple doses of antibody may achieve an increase in labeled MAb concentration in tumors. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {33:9}
journal type = {AC}
place = {Japan}
year = {1993}
month = {Sep}
}