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Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease

Journal Article:

Abstract

The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and sup(99m)Tc-radioaerosol-inhalation lung imaging. Perfusion lung imaging with sup(99m)Tc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P<0.001) was observed between the degree of abnormalities on radio-aerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum midexpiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radio-aerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.
Publication Date:
Apr 01, 1983
Product Type:
Journal Article
Reference Number:
EDB-83-162590
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 8:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AEROSOLS; INHALATION; LUNGS; SCINTISCANNING; RADIOPHARMACEUTICALS; RESPIRATORY SYSTEM DISEASES; DIAGNOSIS; BIOLOGICAL FUNCTIONS; IMAGES; ISOMERIC NUCLEI; PATIENTS; PERFUSED ORGANS; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COLLOIDS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DISPERSIONS; DRUGS; FUNCTIONS; HOURS LIVING RADIOISOTOPES; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM; SOLS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5764495
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
HEDB
Size:
Pages: 167-171
Announcement Date:

Journal Article:

Citation Formats

Garg, A, Pande, J N, Guleria, J S, and Gopinath, P G. Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease. Germany: N. p., 1983. Web.
Garg, A, Pande, J N, Guleria, J S, & Gopinath, P G. Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease. Germany.
Garg, A, Pande, J N, Guleria, J S, and Gopinath, P G. 1983. "Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease." Germany.
@misc{etde_5764495,
title = {Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease}
author = {Garg, A, Pande, J N, Guleria, J S, and Gopinath, P G}
abstractNote = {The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and sup(99m)Tc-radioaerosol-inhalation lung imaging. Perfusion lung imaging with sup(99m)Tc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P<0.001) was observed between the degree of abnormalities on radio-aerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum midexpiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radio-aerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {8:4}
journal type = {AC}
place = {Germany}
year = {1983}
month = {Apr}
}