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Clinical and histological study of pituitary fibrosarcoma following radiotherapy for pituitary adenoma

Journal Article:

Abstract

A 49-year old male was admitted with a history of radiotherapy for a pituitary adenoma 9 years earlier. Three weeks prior to admission, he noticed visual loss in the left eye. Computed tomography (CT) scan revealed a sellar tumor. The patient underwent craniotomy and the tumor was partially resected. The histological diagnosis was benign pituitary adenoma. Two months after surgery, he began to complain of headache and left hemiparesis. CT scan at that time showed a large parasellar tumor extending into the right temporal lobe. A second craniotomy was performed and a firm tumor was partially removed. Under light microscopy, the tumor was composed of anaplastic spindle cells showing a fascicular pattern. Ultrastructurally, the tumor cells were spindle-shaped with elongated nuclei. The cytoplasm contained numerous distended rough endoplasmic reticula and free ribosomes, Golgi apparatus as well as glycogen granules. Some desmosome-like intercellular adherents were observed. Collagen fibers were scattered in the extracellular space. There was no apparent formation of a basement membrane. These findings suggested a close morphological similarity between tumor cells and fibroblasts, conforming to ultrastructural diagnostic criteria for fibrosarcoma. In spite of intensive treatment, such as a second radiotherapy and subsequent craniotomy, the patient died 9 months after  More>>
Authors:
Sato, Kazufumi; Hayashi, Minoru; Kubota, Toshihiko; Kawano, Hirokazu; Handa, Yuji; [1]  Komai, Toshio
  1. Fukui Medical School, Matsuoka (Japan)
Publication Date:
Nov 01, 1990
Product Type:
Journal Article
Reference Number:
JPN-91-004284; EDB-91-078162
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 30:11
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PITUITARY GLAND; DELAYED RADIATION EFFECTS; ADENOMAS; ELECTRON MICROSCOPY; LATENCY PERIOD; PATIENTS; RADIATION INJURIES; RADIOTHERAPY; SARCOMAS; ULTRASTRUCTURAL CHANGES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ENDOCRINE GLANDS; GLANDS; INJURIES; MEDICINE; MICROSCOPY; MORPHOLOGICAL CHANGES; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5759931
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 888-892
Announcement Date:

Journal Article:

Citation Formats

Sato, Kazufumi, Hayashi, Minoru, Kubota, Toshihiko, Kawano, Hirokazu, Handa, Yuji, and Komai, Toshio. Clinical and histological study of pituitary fibrosarcoma following radiotherapy for pituitary adenoma. Japan: N. p., 1990. Web.
Sato, Kazufumi, Hayashi, Minoru, Kubota, Toshihiko, Kawano, Hirokazu, Handa, Yuji, & Komai, Toshio. Clinical and histological study of pituitary fibrosarcoma following radiotherapy for pituitary adenoma. Japan.
Sato, Kazufumi, Hayashi, Minoru, Kubota, Toshihiko, Kawano, Hirokazu, Handa, Yuji, and Komai, Toshio. 1990. "Clinical and histological study of pituitary fibrosarcoma following radiotherapy for pituitary adenoma." Japan.
@misc{etde_5759931,
title = {Clinical and histological study of pituitary fibrosarcoma following radiotherapy for pituitary adenoma}
author = {Sato, Kazufumi, Hayashi, Minoru, Kubota, Toshihiko, Kawano, Hirokazu, Handa, Yuji, and Komai, Toshio}
abstractNote = {A 49-year old male was admitted with a history of radiotherapy for a pituitary adenoma 9 years earlier. Three weeks prior to admission, he noticed visual loss in the left eye. Computed tomography (CT) scan revealed a sellar tumor. The patient underwent craniotomy and the tumor was partially resected. The histological diagnosis was benign pituitary adenoma. Two months after surgery, he began to complain of headache and left hemiparesis. CT scan at that time showed a large parasellar tumor extending into the right temporal lobe. A second craniotomy was performed and a firm tumor was partially removed. Under light microscopy, the tumor was composed of anaplastic spindle cells showing a fascicular pattern. Ultrastructurally, the tumor cells were spindle-shaped with elongated nuclei. The cytoplasm contained numerous distended rough endoplasmic reticula and free ribosomes, Golgi apparatus as well as glycogen granules. Some desmosome-like intercellular adherents were observed. Collagen fibers were scattered in the extracellular space. There was no apparent formation of a basement membrane. These findings suggested a close morphological similarity between tumor cells and fibroblasts, conforming to ultrastructural diagnostic criteria for fibrosarcoma. In spite of intensive treatment, such as a second radiotherapy and subsequent craniotomy, the patient died 9 months after admission. The clinical course and pathological findings of the post-irradiation pituitary fibrosarcoma are discussed. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {30:11}
journal type = {AC}
place = {Japan}
year = {1990}
month = {Nov}
}