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The fate of ingested [sup 14]C-urea in the urea breath test for Helicobacter pylori infection

Journal Article:

Abstract

The metabolic fate of the radioactive carbon in the [sup 14]C-urea breath test for Helicobacter pylori was investigated in 18 subjects. After ingestion of labelled urea, breath was sampled for 24 h, and urine was collected for 3 days. Subjects were designated high or low expirers on the basis of their breath counts, and this agreed well with H. pylori serologic analyses. When given 185 or 37 kBq of [sup 14]C-urea, 51% of the label was recovered from the breath of high expirers, and 7% from the breath of low expirers. The mean combined urinary and breath recovery for high expirers was 86%, and for low expirers it was 97%. It is concluded that the long-term retention of [sup 14]C from ingested [sup 14]C-urea is low. The results enable a more accurate estimation to be made of radiation exposure resulting from the [sup 14]C-urea breath test. 16 refs., 3 figs., 2 tabs.
Authors:
Munster, D J; Chapman, B A; Burt, M J; Dobbs, B R; Allardyce, R A; Bagshaw, P F; Troughton, W D; Cook, H B [1] 
  1. Christchurch Hospital (New Zealand)
Publication Date:
Aug 01, 1993
Product Type:
Journal Article
Reference Number:
AIX-25-000530; EDB-93-160846
Resource Relation:
Journal Name: Scandinavian Journal of Gastroenterology; (Norway); Journal Volume: 28:8
Subject:
60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; DIGESTIVE SYSTEM DISEASES; DIAGNOSTIC TECHNIQUES; LABELLED COMPOUNDS; RADIATION DOSES; CARBON 14; METABOLISM; PATIENTS; RETENTION; UREA; UREASE; AMIDES; AMIDINASES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBONIC ACID DERIVATIVES; DISEASES; DOSES; ENZYMES; EVEN-EVEN NUCLEI; HYDROLASES; ISOTOPES; LIGHT NUCLEI; NON-PEPTIDE C-N HYDROLASES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES; 553006* - Agriculture & Food Technology- Other Agricultural Applications- (1987-); 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5759009
Country of Origin:
Norway
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0036-5521; CODEN: SJGRA4
Submitting Site:
NWN
Size:
Pages: 661-666
Announcement Date:

Journal Article:

Citation Formats

Munster, D J, Chapman, B A, Burt, M J, Dobbs, B R, Allardyce, R A, Bagshaw, P F, Troughton, W D, and Cook, H B. The fate of ingested [sup 14]C-urea in the urea breath test for Helicobacter pylori infection. Norway: N. p., 1993. Web.
Munster, D J, Chapman, B A, Burt, M J, Dobbs, B R, Allardyce, R A, Bagshaw, P F, Troughton, W D, & Cook, H B. The fate of ingested [sup 14]C-urea in the urea breath test for Helicobacter pylori infection. Norway.
Munster, D J, Chapman, B A, Burt, M J, Dobbs, B R, Allardyce, R A, Bagshaw, P F, Troughton, W D, and Cook, H B. 1993. "The fate of ingested [sup 14]C-urea in the urea breath test for Helicobacter pylori infection." Norway.
@misc{etde_5759009,
title = {The fate of ingested [sup 14]C-urea in the urea breath test for Helicobacter pylori infection}
author = {Munster, D J, Chapman, B A, Burt, M J, Dobbs, B R, Allardyce, R A, Bagshaw, P F, Troughton, W D, and Cook, H B}
abstractNote = {The metabolic fate of the radioactive carbon in the [sup 14]C-urea breath test for Helicobacter pylori was investigated in 18 subjects. After ingestion of labelled urea, breath was sampled for 24 h, and urine was collected for 3 days. Subjects were designated high or low expirers on the basis of their breath counts, and this agreed well with H. pylori serologic analyses. When given 185 or 37 kBq of [sup 14]C-urea, 51% of the label was recovered from the breath of high expirers, and 7% from the breath of low expirers. The mean combined urinary and breath recovery for high expirers was 86%, and for low expirers it was 97%. It is concluded that the long-term retention of [sup 14]C from ingested [sup 14]C-urea is low. The results enable a more accurate estimation to be made of radiation exposure resulting from the [sup 14]C-urea breath test. 16 refs., 3 figs., 2 tabs.}
journal = {Scandinavian Journal of Gastroenterology; (Norway)}
volume = {28:8}
journal type = {AC}
place = {Norway}
year = {1993}
month = {Aug}
}