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Radioimmunoassay of sodium cromoglycate in human plasma

Journal Article:

Abstract

A sensitive radioimmunoassay method for sodium cromoglycate in human plasma is described. The lowest quantifiable concentration of sodium cromoglycate is 0.93 nmol/l when 0.1 ml plasma samples are analysed. The range of the method is limited; both 0.01 and 0.1 ml volumes of plasma must be analysed to encompass the concentration range 0.93-139 nmol/l which may be encountered in plasma samples from patients and human volunteers. The method is specific for sodium cromoglycate as indicated by a low cross-reactivity of the anti-cromoglycate antiserum with a number of drugs.
Authors:
Brown, K; Gardner, J J; Lockley, W J.S.; Preston, J R; Wilkinson, D J [1] 
  1. Fisons plc, Loughborough (UK). Pharmaceutical Div.
Publication Date:
Jan 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-14-792231; EDB-83-193839
Resource Relation:
Journal Name: Ann. Clin. Biochem.; (United Kingdom); Journal Volume: 20
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD PLASMA; RADIOIMMUNOASSAY; CARBOXYLIC ACID ESTERS; ANTIBODIES; ASTHMA; DRUGS; QUANTITY RATIO; SENSITIVITY; SODIUM COMPOUNDS; TIME DEPENDENCE; ALKALI METAL COMPOUNDS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; DISEASES; ESTERS; ISOTOPE APPLICATIONS; MATERIALS; ORGANIC COMPOUNDS; RADIOASSAY; RESPIRATORY SYSTEM DISEASES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5745196
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ACBOB
Submitting Site:
HEDB
Size:
Pages: 31-36
Announcement Date:
Sep 01, 1983

Journal Article:

Citation Formats

Brown, K, Gardner, J J, Lockley, W J.S., Preston, J R, and Wilkinson, D J. Radioimmunoassay of sodium cromoglycate in human plasma. United Kingdom: N. p., 1983. Web.
Brown, K, Gardner, J J, Lockley, W J.S., Preston, J R, & Wilkinson, D J. Radioimmunoassay of sodium cromoglycate in human plasma. United Kingdom.
Brown, K, Gardner, J J, Lockley, W J.S., Preston, J R, and Wilkinson, D J. 1983. "Radioimmunoassay of sodium cromoglycate in human plasma." United Kingdom.
@misc{etde_5745196,
title = {Radioimmunoassay of sodium cromoglycate in human plasma}
author = {Brown, K, Gardner, J J, Lockley, W J.S., Preston, J R, and Wilkinson, D J}
abstractNote = {A sensitive radioimmunoassay method for sodium cromoglycate in human plasma is described. The lowest quantifiable concentration of sodium cromoglycate is 0.93 nmol/l when 0.1 ml plasma samples are analysed. The range of the method is limited; both 0.01 and 0.1 ml volumes of plasma must be analysed to encompass the concentration range 0.93-139 nmol/l which may be encountered in plasma samples from patients and human volunteers. The method is specific for sodium cromoglycate as indicated by a low cross-reactivity of the anti-cromoglycate antiserum with a number of drugs.}
journal = {Ann. Clin. Biochem.; (United Kingdom)}
volume = {20}
journal type = {AC}
place = {United Kingdom}
year = {1983}
month = {Jan}
}