Abstract
The renal imaging agent, Tc-Sn-DMSA complex is usually prepared under acidic conditions by successive addition of SnCl/sub 2/ and TcO/sub 4/- to DMSA. We found evidence of significant yields of reduced uncomplexed technetium in such solutions. The efficacy of the labelled solution may be influenced by the presence of this species. So we have investigated a more reliable synthesis method and made an attempt to elucidate the structure of the labelled complex. Sn-DMSA complex has been studied by potentiometric titrations and evidence has been given of a stable 1/1, Sn/DMSA complex at pH >= 7. Labelling reaction parameters (pH, molar ratio Sn/sup + +//DMSA, carrier Tc) have been varied and optimal values chosen. The labelling procedure defined is unconventional and gives 90% complex DMSA-Sn-Tc and a few percents reduced uncomplexed technetium. Complex stability has been studied as a function of pH, dilution and time. The complex carries a net charge of -4. We suggest a 2/1DMSA-Tc(IV) complex with a structure containing two five-membered rings involving two mercapto groups from each DMSA.
Laroche, D;
Travert, G;
[1]
Guillaumont, R
[2]
- Centre Hospitalier Universitaire, 14 - Caen (France)
- Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire
Citation Formats
Laroche, D, Travert, G, and Guillaumont, R.
Chemical and biological study of a renal imaging agent. I. preparation and structure of DMSA, Sn, Tc complex.
France: N. p.,
1978.
Web.
Laroche, D, Travert, G, & Guillaumont, R.
Chemical and biological study of a renal imaging agent. I. preparation and structure of DMSA, Sn, Tc complex.
France.
Laroche, D, Travert, G, and Guillaumont, R.
1978.
"Chemical and biological study of a renal imaging agent. I. preparation and structure of DMSA, Sn, Tc complex."
France.
@misc{etde_5738495,
title = {Chemical and biological study of a renal imaging agent. I. preparation and structure of DMSA, Sn, Tc complex}
author = {Laroche, D, Travert, G, and Guillaumont, R}
abstractNote = {The renal imaging agent, Tc-Sn-DMSA complex is usually prepared under acidic conditions by successive addition of SnCl/sub 2/ and TcO/sub 4/- to DMSA. We found evidence of significant yields of reduced uncomplexed technetium in such solutions. The efficacy of the labelled solution may be influenced by the presence of this species. So we have investigated a more reliable synthesis method and made an attempt to elucidate the structure of the labelled complex. Sn-DMSA complex has been studied by potentiometric titrations and evidence has been given of a stable 1/1, Sn/DMSA complex at pH >= 7. Labelling reaction parameters (pH, molar ratio Sn/sup + +//DMSA, carrier Tc) have been varied and optimal values chosen. The labelling procedure defined is unconventional and gives 90% complex DMSA-Sn-Tc and a few percents reduced uncomplexed technetium. Complex stability has been studied as a function of pH, dilution and time. The complex carries a net charge of -4. We suggest a 2/1DMSA-Tc(IV) complex with a structure containing two five-membered rings involving two mercapto groups from each DMSA.}
journal = []
volume = {4}
journal type = {AC}
place = {France}
year = {1978}
month = {Jan}
}
title = {Chemical and biological study of a renal imaging agent. I. preparation and structure of DMSA, Sn, Tc complex}
author = {Laroche, D, Travert, G, and Guillaumont, R}
abstractNote = {The renal imaging agent, Tc-Sn-DMSA complex is usually prepared under acidic conditions by successive addition of SnCl/sub 2/ and TcO/sub 4/- to DMSA. We found evidence of significant yields of reduced uncomplexed technetium in such solutions. The efficacy of the labelled solution may be influenced by the presence of this species. So we have investigated a more reliable synthesis method and made an attempt to elucidate the structure of the labelled complex. Sn-DMSA complex has been studied by potentiometric titrations and evidence has been given of a stable 1/1, Sn/DMSA complex at pH >= 7. Labelling reaction parameters (pH, molar ratio Sn/sup + +//DMSA, carrier Tc) have been varied and optimal values chosen. The labelling procedure defined is unconventional and gives 90% complex DMSA-Sn-Tc and a few percents reduced uncomplexed technetium. Complex stability has been studied as a function of pH, dilution and time. The complex carries a net charge of -4. We suggest a 2/1DMSA-Tc(IV) complex with a structure containing two five-membered rings involving two mercapto groups from each DMSA.}
journal = []
volume = {4}
journal type = {AC}
place = {France}
year = {1978}
month = {Jan}
}