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Increased binding of (/sup 3/H)apomorphine in caudate membranes after dopamine pretreatment in vitro

Journal Article:

Abstract

Most patients with Parkinson's disease treated with L-dopa show a progressively deteriorating response which may possibly be attributed to an L-dopa-induced process of unknown origin. Long-term administration of dopamine-mimetic drugs to animals sometimes produces behavioural facilitation. To investigate one possible molecular mechanism of this facilitation or sensitization the effects of prolonged exposure, in vitro, of dopamine on the dopamine/neuroleptic receptors in the caudate nucleus of the calf were tested. Calf caudate homogenates pretreated with dopamine or other drugs were tested for the binding of (/sup 3/H)apomorphine, (/sup 3/H)haloperidol, 3H-WB-4101, or (/sup 3/H)naloxine. Pre-exposure with dopamine or noradrenaline lead to an increased binding of (/sup 3/H)apomorphine. The significance of the results is discussed.
Authors:
McManus, C; Hartley, E J; Seeman, P [1] 
  1. Toronto Univ., Ontario (Canada)
Publication Date:
Jul 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-437089; EDB-80-012923
Resource Relation:
Journal Name: J. Pharm. Pharmacol.; (United Kingdom); Journal Volume: 30:7
Subject:
59 BASIC BIOLOGICAL SCIENCES; DOPAMINE; BIOCHEMICAL REACTION KINETICS; MORPHINE; RECEPTORS; BRAIN; DOPA; HOMOGENATES; IN VITRO; LABELLED COMPOUNDS; LIGANDS; MEMBRANES; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ALKALOIDS; AMINES; AMINO ACIDS; ANALGESICS; AROMATICS; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; DRUGS; HYDROXY ACIDS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; KINETICS; NARCOTICS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; REACTION KINETICS; SYMPATHOMIMETICS; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
5734607
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JPPMA
Submitting Site:
INIS
Size:
Pages: 444-447
Announcement Date:

Journal Article:

Citation Formats

McManus, C, Hartley, E J, and Seeman, P. Increased binding of (/sup 3/H)apomorphine in caudate membranes after dopamine pretreatment in vitro. United Kingdom: N. p., 1978. Web.
McManus, C, Hartley, E J, & Seeman, P. Increased binding of (/sup 3/H)apomorphine in caudate membranes after dopamine pretreatment in vitro. United Kingdom.
McManus, C, Hartley, E J, and Seeman, P. 1978. "Increased binding of (/sup 3/H)apomorphine in caudate membranes after dopamine pretreatment in vitro." United Kingdom.
@misc{etde_5734607,
title = {Increased binding of (/sup 3/H)apomorphine in caudate membranes after dopamine pretreatment in vitro}
author = {McManus, C, Hartley, E J, and Seeman, P}
abstractNote = {Most patients with Parkinson's disease treated with L-dopa show a progressively deteriorating response which may possibly be attributed to an L-dopa-induced process of unknown origin. Long-term administration of dopamine-mimetic drugs to animals sometimes produces behavioural facilitation. To investigate one possible molecular mechanism of this facilitation or sensitization the effects of prolonged exposure, in vitro, of dopamine on the dopamine/neuroleptic receptors in the caudate nucleus of the calf were tested. Calf caudate homogenates pretreated with dopamine or other drugs were tested for the binding of (/sup 3/H)apomorphine, (/sup 3/H)haloperidol, 3H-WB-4101, or (/sup 3/H)naloxine. Pre-exposure with dopamine or noradrenaline lead to an increased binding of (/sup 3/H)apomorphine. The significance of the results is discussed.}
journal = {J. Pharm. Pharmacol.; (United Kingdom)}
volume = {30:7}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jul}
}