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Human exposure to bovine polyomavirus: a zoonosis

Abstract

A competitive-type solid phase radioimmunoassay (RIA) was developed for the detection of antibody to bovine polyomavirus. Comparison of RIA and counter-immunoelectrophoresis (CIE) results on 273 cattle sera indicated that both techniques were detecting antibody of like specificity. Human sera from 256 blood donors, 219 people recently vaccinated against polio, rubella or rabies, 50 immunosuppressed patients and 472 people with various occupational exposure to cattle were tested for antibody to bovine polyomavirus, the foetal rhesus monkey kidney strain, (anti-FRKV) by RIA. Apart from one blood donor and one of 108 rabies vaccinees only those in close contact with cattle possessed anti-FRKV. Compared with 62 per cent seropositive in the natural hosts, cattle, 71 per cent of veterinary surgeons, 50 per cent of cattle farmers, 40 per cent of abattoir workers, 16 per cent of veterinary institute technical staff and 10 per cent of veterinary students were anti-FRKV positive. Our findings indicate that the theoretical hazard of FRKV infection from undetected contamination of current tissue culture derived vaccines may, in practice, be remote. Proposed wider use of primate kidney cells as substrates for new vaccines may increase this risk.
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
EDB-86-104388
Resource Relation:
Journal Name: Arch. Virol.; (Austria); Journal Volume: 3-4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; RADIOIMMUNOASSAY; BLOOD SERUM; CATTLE; MAN; OCCUPATIONAL EXPOSURE; VETERINARY MEDICINE; VIRUSES; ANIMALS; DOMESTIC ANIMALS; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MAMMALS; MEDICINE; MICROORGANISMS; PARASITES; PRIMATES; RADIOASSAY; RADIOIMMUNOLOGY; RUMINANTS; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5733679
Research Organizations:
Central Public Health Lab., London, England
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ARVID
Submitting Site:
NLM
Size:
Pages: 287-296
Announcement Date:

Citation Formats

Parry, J V, and Gardner, S D. Human exposure to bovine polyomavirus: a zoonosis. Austria: N. p., 1986. Web. doi:10.1007/BF01315306.
Parry, J V, & Gardner, S D. Human exposure to bovine polyomavirus: a zoonosis. Austria. doi:10.1007/BF01315306.
Parry, J V, and Gardner, S D. 1986. "Human exposure to bovine polyomavirus: a zoonosis." Austria. doi:10.1007/BF01315306. https://www.osti.gov/servlets/purl/10.1007/BF01315306.
@misc{etde_5733679,
title = {Human exposure to bovine polyomavirus: a zoonosis}
author = {Parry, J V, and Gardner, S D}
abstractNote = {A competitive-type solid phase radioimmunoassay (RIA) was developed for the detection of antibody to bovine polyomavirus. Comparison of RIA and counter-immunoelectrophoresis (CIE) results on 273 cattle sera indicated that both techniques were detecting antibody of like specificity. Human sera from 256 blood donors, 219 people recently vaccinated against polio, rubella or rabies, 50 immunosuppressed patients and 472 people with various occupational exposure to cattle were tested for antibody to bovine polyomavirus, the foetal rhesus monkey kidney strain, (anti-FRKV) by RIA. Apart from one blood donor and one of 108 rabies vaccinees only those in close contact with cattle possessed anti-FRKV. Compared with 62 per cent seropositive in the natural hosts, cattle, 71 per cent of veterinary surgeons, 50 per cent of cattle farmers, 40 per cent of abattoir workers, 16 per cent of veterinary institute technical staff and 10 per cent of veterinary students were anti-FRKV positive. Our findings indicate that the theoretical hazard of FRKV infection from undetected contamination of current tissue culture derived vaccines may, in practice, be remote. Proposed wider use of primate kidney cells as substrates for new vaccines may increase this risk.}
doi = {10.1007/BF01315306}
journal = {Arch. Virol.; (Austria)}
volume = {3-4}
journal type = {AC}
place = {Austria}
year = {1986}
month = {Jan}
}