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Sensitivity test of tumor cell to anticancer drug using diffusion chamber

Journal Article:

Abstract

The diffusion chamber method and xenogeneic transplantation of human cancer cells in rats were studied clinically to test the sensitivity of these cells to anticancer drugs. The growth of Hirosaki sarcoma in a diffusion chamber inserted in to Wistar rats was influenced by the difference in tumor cell counts in the chamber. The growth rate in the chamber inserted in to the subcutaneous tissue was more constant than in the abdominal cavity, but the degree of proliferation of tumor cells in the abdominal cavity was more than in the subcutaneous tissue. Sarcoma and solid type sarcoma were affected by mitomycin C (MMC). The effect was greater in dd-mice than in Donryu rats. Solid type Yoshida sarcoma inserted in to the subcutaneous tissue of Donryu rat was not affected by MMC. The degree of sensitivity of methylcholanthrene induced tumor cells, inserted in to the subcutaneous tissue of Donryu rats, to MMC differed according to various conditions of the hosts. Clinically, the influences of anticancer drugs on human cancer cells inserted in to the subcutaneous tissue of /sup 60/Co-irradiated Donryu rats were observed. There were various grades of sensitivity of gastric cancer cells to anticancer drugs. MMC was effective in 53% of  More>>
Authors:
Soejima, S [1] 
  1. Hirosaki Univ., Aomori (Japan). School of Medicine
Publication Date:
Nov 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-476661; EDB-80-013080
Resource Relation:
Journal Name: Saishin Igaku; (Japan); Journal Volume: 33:11
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; SARCOMAS; CHEMOTHERAPY; ENDOXAN; FLUOROURACILS; GAMMA RADIATION; MICE; MITOMYCIN; RATS; SENSITIVITY; THYMIDINE; TISSUE CULTURES; TRACER TECHNIQUES; TRITIUM COMPOUNDS; TUMOR CELLS; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANIMAL CELLS; ANIMALS; ANTIBIOTICS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; NEOPLASMS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATIONS; RIBOSIDES; RODENTS; THERAPY; URACILS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5733494
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: SAIGA
Submitting Site:
INIS
Size:
Pages: 2278-2288
Announcement Date:

Journal Article:

Citation Formats

Soejima, S. Sensitivity test of tumor cell to anticancer drug using diffusion chamber. Japan: N. p., 1978. Web.
Soejima, S. Sensitivity test of tumor cell to anticancer drug using diffusion chamber. Japan.
Soejima, S. 1978. "Sensitivity test of tumor cell to anticancer drug using diffusion chamber." Japan.
@misc{etde_5733494,
title = {Sensitivity test of tumor cell to anticancer drug using diffusion chamber}
author = {Soejima, S}
abstractNote = {The diffusion chamber method and xenogeneic transplantation of human cancer cells in rats were studied clinically to test the sensitivity of these cells to anticancer drugs. The growth of Hirosaki sarcoma in a diffusion chamber inserted in to Wistar rats was influenced by the difference in tumor cell counts in the chamber. The growth rate in the chamber inserted in to the subcutaneous tissue was more constant than in the abdominal cavity, but the degree of proliferation of tumor cells in the abdominal cavity was more than in the subcutaneous tissue. Sarcoma and solid type sarcoma were affected by mitomycin C (MMC). The effect was greater in dd-mice than in Donryu rats. Solid type Yoshida sarcoma inserted in to the subcutaneous tissue of Donryu rat was not affected by MMC. The degree of sensitivity of methylcholanthrene induced tumor cells, inserted in to the subcutaneous tissue of Donryu rats, to MMC differed according to various conditions of the hosts. Clinically, the influences of anticancer drugs on human cancer cells inserted in to the subcutaneous tissue of /sup 60/Co-irradiated Donryu rats were observed. There were various grades of sensitivity of gastric cancer cells to anticancer drugs. MMC was effective in 53% of the cases, Cyclophosphamide in 40%, 5-FU in 54%, cytosine arabinoside in 32%, and FT-207 in 57%. Twenty-seven percent were not affected by anticancer drugs. On histological examination, tubular adenocarcinoma cells had a high sensitivity to anticancer drugs, while poorly differentiated adenocarcinoma cells had a low sensitive. Anticancer drugs selected according to the sensitivity of human cancer cells had a marked effective on advanced cancer cells. The diffusion chamber method was useful in determining the degree of bone marrow toxicity of anticancer drugs.}
journal = {Saishin Igaku; (Japan)}
volume = {33:11}
journal type = {AC}
place = {Japan}
year = {1978}
month = {Nov}
}