Abstract
In vitro double labeling autoradiography for measuring the labeling index, duration of S phase and potential doubling time has been used to assess the effect of a single and fractionated test dose of irradiation in uterine cervix cancer applied in 21 patients. Tumor-labeling index fell significantly in those tumors which had a high labeling index before irradiation, and these cases were found later to exhibit a good radiation response. Duration of S phase which ranged between 9 and 27 hours prior to irradiation was increased. Differences between the potential doubling time and the actual doubling time suggest a massive cell loss in tumors which were, for the most part, of exophytic type. Fractionated irradiation provides more reliable informations than a single dose and is useful for investigation of dynamic changes in the kinetics of an asynchronous cell population.
Siracka, E;
Siracky, J;
Pappova, N;
[1]
Schreiner, P
[2]
- Slovenska Akademia Vied, Bratislava (Czechoslovakia). Cancer Research Inst.
- Komenskeho Univ., Bratislava (Czechoslovakia). Chair of Oncology and Radiology
Citation Formats
Siracka, E, Siracky, J, Pappova, N, and Schreiner, P.
Radiation-induced changes in cell proliferation kinetics in uterine cervix cancer.
Germany: N. p.,
1979.
Web.
Siracka, E, Siracky, J, Pappova, N, & Schreiner, P.
Radiation-induced changes in cell proliferation kinetics in uterine cervix cancer.
Germany.
Siracka, E, Siracky, J, Pappova, N, and Schreiner, P.
1979.
"Radiation-induced changes in cell proliferation kinetics in uterine cervix cancer."
Germany.
@misc{etde_5733056,
title = {Radiation-induced changes in cell proliferation kinetics in uterine cervix cancer}
author = {Siracka, E, Siracky, J, Pappova, N, and Schreiner, P}
abstractNote = {In vitro double labeling autoradiography for measuring the labeling index, duration of S phase and potential doubling time has been used to assess the effect of a single and fractionated test dose of irradiation in uterine cervix cancer applied in 21 patients. Tumor-labeling index fell significantly in those tumors which had a high labeling index before irradiation, and these cases were found later to exhibit a good radiation response. Duration of S phase which ranged between 9 and 27 hours prior to irradiation was increased. Differences between the potential doubling time and the actual doubling time suggest a massive cell loss in tumors which were, for the most part, of exophytic type. Fractionated irradiation provides more reliable informations than a single dose and is useful for investigation of dynamic changes in the kinetics of an asynchronous cell population.}
journal = []
volume = {155:6}
journal type = {AC}
place = {Germany}
year = {1979}
month = {Jun}
}
title = {Radiation-induced changes in cell proliferation kinetics in uterine cervix cancer}
author = {Siracka, E, Siracky, J, Pappova, N, and Schreiner, P}
abstractNote = {In vitro double labeling autoradiography for measuring the labeling index, duration of S phase and potential doubling time has been used to assess the effect of a single and fractionated test dose of irradiation in uterine cervix cancer applied in 21 patients. Tumor-labeling index fell significantly in those tumors which had a high labeling index before irradiation, and these cases were found later to exhibit a good radiation response. Duration of S phase which ranged between 9 and 27 hours prior to irradiation was increased. Differences between the potential doubling time and the actual doubling time suggest a massive cell loss in tumors which were, for the most part, of exophytic type. Fractionated irradiation provides more reliable informations than a single dose and is useful for investigation of dynamic changes in the kinetics of an asynchronous cell population.}
journal = []
volume = {155:6}
journal type = {AC}
place = {Germany}
year = {1979}
month = {Jun}
}