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Erythrokinetics in mice bearing tumours in either preirradiated or unirradiated tissue

Journal Article:

Abstract

Experiments were designed to clarify the causes of anaemia in hosts bearing tumours in either unirradiated or preirradiated tissue. Isotopic methods are described which enable the estimation of erythrocyte destruction and production rates, and the potential red cell life spans in tumour-bearing animals. In this experimental system, anaemia (a) is in large part due to accelerated random erythrocyte loss, (b) is exacerbated as tumours grow by a progressive reduction in the potential erythrocyte life span due to intrinsic erythrocyte defects. (c) is accompanied by an increase in erythrocyte production of six- to ten-fold and (d) is postponed in onset and decreased in magnitude by preirradiation of the tumour transplant site.
Authors:
Jirtle, R L; Clifton, K H [1] 
  1. Wisconsin Univ., Madison (USA). Div. of Clinical Oncology
Publication Date:
Nov 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-463134; EDB-80-037507
Resource Relation:
Journal Name: Cell Tissue Kinet.; (United Kingdom); Journal Volume: 11:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANEMIAS; ERYTHROCYTES; KINETICS; BIOLOGICAL RADIATION EFFECTS; CARBON 14; CELL KILLING; CELL PROLIFERATION; EXPERIMENTAL DATA; GRAPHS; HOST; IRON 59; IRRADIATION; LABELLING; LIFE SPAN; MICE; NEOPLASMS; SURVIVAL CURVES; TABLES; TECHNETIUM 99; THEORETICAL DATA; TISSUES; TRANSPLANTS; X RADIATION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARBON ISOTOPES; DATA; DATA FORMS; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTROMAGNETIC RADIATION; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HEMIC DISEASES; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; IRON ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SYMPTOMS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells
OSTI ID:
5729776
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CTKIA
Submitting Site:
INIS
Size:
Pages: 581-596
Announcement Date:

Journal Article:

Citation Formats

Jirtle, R L, and Clifton, K H. Erythrokinetics in mice bearing tumours in either preirradiated or unirradiated tissue. United Kingdom: N. p., 1978. Web.
Jirtle, R L, & Clifton, K H. Erythrokinetics in mice bearing tumours in either preirradiated or unirradiated tissue. United Kingdom.
Jirtle, R L, and Clifton, K H. 1978. "Erythrokinetics in mice bearing tumours in either preirradiated or unirradiated tissue." United Kingdom.
@misc{etde_5729776,
title = {Erythrokinetics in mice bearing tumours in either preirradiated or unirradiated tissue}
author = {Jirtle, R L, and Clifton, K H}
abstractNote = {Experiments were designed to clarify the causes of anaemia in hosts bearing tumours in either unirradiated or preirradiated tissue. Isotopic methods are described which enable the estimation of erythrocyte destruction and production rates, and the potential red cell life spans in tumour-bearing animals. In this experimental system, anaemia (a) is in large part due to accelerated random erythrocyte loss, (b) is exacerbated as tumours grow by a progressive reduction in the potential erythrocyte life span due to intrinsic erythrocyte defects. (c) is accompanied by an increase in erythrocyte production of six- to ten-fold and (d) is postponed in onset and decreased in magnitude by preirradiation of the tumour transplant site.}
journal = {Cell Tissue Kinet.; (United Kingdom)}
volume = {11:6}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Nov}
}