You need JavaScript to view this

Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product

Journal Article:

Abstract

A set of mouse monoclonal antibodies against the c-myc oncogene product, a 62,000 dalton nuclear binding protein involved in cell cycle control, has been constructed by immunisation with synthetic peptide fragments. One such antibody, CT14, was radiolabelled with /sup 131/I and administered to 20 patients with different malignant diseases. Good tumour localisation was observed in 12 out of 14 patients with primary bronchial carcinoma but not in patients with pulmonary metastases from primary tumours elsewhere. Successfully localised tumours were all 3 cm or more in diameter. Monoclonal antibodies against oncogene products may provide novel selective tools for the diagnosis and therapy of cancer.
Publication Date:
Nov 01, 1986
Product Type:
Journal Article
Reference Number:
GBN-87-000674; EDB-88-020801
Resource Relation:
Journal Name: Br. J. Cancer; (United Kingdom); Journal Volume: 54:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; RADIOIMMUNOSCINTIGRAPHY; LUNGS; NUCLEOPROTEINS; RADIOIMMUNOASSAY; DIAGNOSIS; GROWTH FACTORS; IODINE 131; MEMBRANE PROTEINS; MONOCLONAL ANTIBODIES; NUCLEAR MEDICINE; ONCOGENES; RADIOTHERAPY; RECEPTORS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; GENES; IMMUNOASSAY; IMMUNOLOGY; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MEDICINE; MITOGENS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY; RESPIRATORY SYSTEM; SCINTISCANNING; THERAPY; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5724570
Research Organizations:
MRC Centre, Cambridge, GB. Ludwig Inst. for Cancer Research; Addenbrooke's Hospital, Cambridge, UK; Royal Postgraduate Medical School, London, UK
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJCAA
Submitting Site:
GBN
Size:
Pages: 761-769
Announcement Date:

Journal Article:

Citation Formats

Chan, S Y.T., Evan, G I, Ritson, A, Watson, J, Wraight, P, and Sikora, K. Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product. United Kingdom: N. p., 1986. Web.
Chan, S Y.T., Evan, G I, Ritson, A, Watson, J, Wraight, P, & Sikora, K. Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product. United Kingdom.
Chan, S Y.T., Evan, G I, Ritson, A, Watson, J, Wraight, P, and Sikora, K. 1986. "Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product." United Kingdom.
@misc{etde_5724570,
title = {Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product}
author = {Chan, S Y.T., Evan, G I, Ritson, A, Watson, J, Wraight, P, and Sikora, K}
abstractNote = {A set of mouse monoclonal antibodies against the c-myc oncogene product, a 62,000 dalton nuclear binding protein involved in cell cycle control, has been constructed by immunisation with synthetic peptide fragments. One such antibody, CT14, was radiolabelled with /sup 131/I and administered to 20 patients with different malignant diseases. Good tumour localisation was observed in 12 out of 14 patients with primary bronchial carcinoma but not in patients with pulmonary metastases from primary tumours elsewhere. Successfully localised tumours were all 3 cm or more in diameter. Monoclonal antibodies against oncogene products may provide novel selective tools for the diagnosis and therapy of cancer.}
journal = {Br. J. Cancer; (United Kingdom)}
volume = {54:5}
journal type = {AC}
place = {United Kingdom}
year = {1986}
month = {Nov}
}