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Infarct size in patients with acute myocardial infarction estimated by emission computed tomography with technetium-99m pyrophosphate. Relation to creatine phosphokinase release

Journal Article:

Abstract

To evaluate the usefulness of single photon emission computed tomography (SPECT) with technetium-99m-pyrophosphate (/sup 99m/Tc-PYP) for estimating infarct size, we compared SPECT data with maximum creatine phosphokinase values. Background threshold was established in a series of phantom experiments. When a 40 % cut-off was applied, the SPECT data most closely approximated actual phantom volumes. Therefore, the 40 % cut-off level was used in the present study. In 10 patients with acute myocardial infarction, planar /sup 99m/Tc-PYP myocardial scintigraphy and SPECT using a rotating gamma camera were performed two days after the initial myocardial infarction episode. The maximum creatine phosphokinase value (CPKmax) was also measured repeatedly following the episode. When the infarct size measured by SPECT using transaxial images and calculated by the pixel counts, it correlated very closely with CPKmax (r = 0.94). Most studies so far have reported that the CPKmax level reflects infarct size. We conclude that the infarct size as measured by /sup 99m/Tc-PYP SPECT closely approximates the actual infarct size, and that this method is useful to determine the severity of infarcts clinically. Among the 10 patients in this series, three of five with infarcts greater than 60 ml died of pump failure. Therefore, we may  More>>
Publication Date:
Sep 01, 1986
Product Type:
Journal Article
Reference Number:
JPN-87-060459; EDB-88-020805
Resource Relation:
Journal Name: J. Cardiogr.; (Japan); Journal Volume: 16:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIUM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; CREATINE; DATA PROCESSING; MYOCARDIAL INFARCTION; PATIENTS; PHANTOMS; PHOSPHOTRANSFERASES; PYROPHOSPHATES; SIZE; TECHNETIUM 99; UPTAKE; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; ENZYMES; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MOCKUP; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PROCESSING; RADIOISOTOPES; STRUCTURAL MODELS; TECHNETIUM ISOTOPES; TOMOGRAPHY; TRANSFERASES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5724512
Research Organizations:
Asahikawa Medical Coll., Hokkaido, Japan
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: JOCAD
Submitting Site:
JPN
Size:
Pages: 545-553
Announcement Date:

Journal Article:

Citation Formats

Maruyama, Jun-ichi, Onodera, Sokichi, Imura, Suguru, Marutani, Yoshiaki, Takahori, Takashi, and Nasuhara, Koh-ichi. Infarct size in patients with acute myocardial infarction estimated by emission computed tomography with technetium-99m pyrophosphate. Relation to creatine phosphokinase release. Japan: N. p., 1986. Web.
Maruyama, Jun-ichi, Onodera, Sokichi, Imura, Suguru, Marutani, Yoshiaki, Takahori, Takashi, & Nasuhara, Koh-ichi. Infarct size in patients with acute myocardial infarction estimated by emission computed tomography with technetium-99m pyrophosphate. Relation to creatine phosphokinase release. Japan.
Maruyama, Jun-ichi, Onodera, Sokichi, Imura, Suguru, Marutani, Yoshiaki, Takahori, Takashi, and Nasuhara, Koh-ichi. 1986. "Infarct size in patients with acute myocardial infarction estimated by emission computed tomography with technetium-99m pyrophosphate. Relation to creatine phosphokinase release." Japan.
@misc{etde_5724512,
title = {Infarct size in patients with acute myocardial infarction estimated by emission computed tomography with technetium-99m pyrophosphate. Relation to creatine phosphokinase release}
author = {Maruyama, Jun-ichi, Onodera, Sokichi, Imura, Suguru, Marutani, Yoshiaki, Takahori, Takashi, and Nasuhara, Koh-ichi}
abstractNote = {To evaluate the usefulness of single photon emission computed tomography (SPECT) with technetium-99m-pyrophosphate (/sup 99m/Tc-PYP) for estimating infarct size, we compared SPECT data with maximum creatine phosphokinase values. Background threshold was established in a series of phantom experiments. When a 40 % cut-off was applied, the SPECT data most closely approximated actual phantom volumes. Therefore, the 40 % cut-off level was used in the present study. In 10 patients with acute myocardial infarction, planar /sup 99m/Tc-PYP myocardial scintigraphy and SPECT using a rotating gamma camera were performed two days after the initial myocardial infarction episode. The maximum creatine phosphokinase value (CPKmax) was also measured repeatedly following the episode. When the infarct size measured by SPECT using transaxial images and calculated by the pixel counts, it correlated very closely with CPKmax (r = 0.94). Most studies so far have reported that the CPKmax level reflects infarct size. We conclude that the infarct size as measured by /sup 99m/Tc-PYP SPECT closely approximates the actual infarct size, and that this method is useful to determine the severity of infarcts clinically. Among the 10 patients in this series, three of five with infarcts greater than 60 ml died of pump failure. Therefore, we may be able to predict prognosis after accumulating more such cases and improving the methodology.}
journal = {J. Cardiogr.; (Japan)}
volume = {16:3}
journal type = {AC}
place = {Japan}
year = {1986}
month = {Sep}
}