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Three dimensional cerebral blood flow in patients with idiopathic Parkinson's disease

Journal Article:

Abstract

Three dimensional local cerebral blood flow values were measured in 28 patients with idiopathic Parkinson's disease without dementia and 17 control subjects, by means of xenon enhanced CT method using low concentration cold xenon and autoradiographic strategy. The results demonstrated that local cerebral perfusion in the patients with Parkinson's disease decreased with close correlations with aging and severity of the clinical symptoms and signs. Stepwise multiregression analysis revealed that mean CBF values and 1-CBF values through thalamus and white matter decreased primarily depending on aging and degree of brain atrophy, whereas 1-CBF values through basal ganglia decreased depending on severity of disease. The spatial distributions of 1-CBF were maintained normally and symmetrically even in the severely affected cases or in those with hemiparkinsonism, therefore hyperfrontalities were well preserved in all of the patients. Acute intravenous administration of L-DOPA gave rise to a diffuse increase in 1-CBF only in the patients and the increment was more prominent in patients severely affected than in those mildly affected. It was concluded that reduction of 1-CBF in the basal ganglia and cortex may be attributed to hypometabolism in the mesostriatal and mesocortical dopaminergic system.
Authors:
Publication Date:
Jul 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-87-060519; EDB-88-020967
Resource Relation:
Journal Name: Keio Igaku; (Japan); Journal Volume: 64:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; CAT SCANNING; AGE DEPENDENCE; ATROPHY; AUTORADIOGRAPHY; BLOOD FLOW; DOPA; IMAGES; NERVOUS SYSTEM DISEASES; PATIENTS; THREE-DIMENSIONAL CALCULATIONS; XENON; AMINO ACIDS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; BRAIN; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELEMENTS; FLUIDS; GASES; HYDROXY ACIDS; NERVOUS SYSTEM; NEUROREGULATORS; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RARE GASES; TOMOGRAPHY; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5723815
Research Organizations:
Keio Univ., Tokyo, Japan. School of Medicine
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KEIGA
Submitting Site:
JPN
Size:
Pages: 495-511
Announcement Date:

Journal Article:

Citation Formats

Hata, Takashi. Three dimensional cerebral blood flow in patients with idiopathic Parkinson's disease. Japan: N. p., 1987. Web.
Hata, Takashi. Three dimensional cerebral blood flow in patients with idiopathic Parkinson's disease. Japan.
Hata, Takashi. 1987. "Three dimensional cerebral blood flow in patients with idiopathic Parkinson's disease." Japan.
@misc{etde_5723815,
title = {Three dimensional cerebral blood flow in patients with idiopathic Parkinson's disease}
author = {Hata, Takashi}
abstractNote = {Three dimensional local cerebral blood flow values were measured in 28 patients with idiopathic Parkinson's disease without dementia and 17 control subjects, by means of xenon enhanced CT method using low concentration cold xenon and autoradiographic strategy. The results demonstrated that local cerebral perfusion in the patients with Parkinson's disease decreased with close correlations with aging and severity of the clinical symptoms and signs. Stepwise multiregression analysis revealed that mean CBF values and 1-CBF values through thalamus and white matter decreased primarily depending on aging and degree of brain atrophy, whereas 1-CBF values through basal ganglia decreased depending on severity of disease. The spatial distributions of 1-CBF were maintained normally and symmetrically even in the severely affected cases or in those with hemiparkinsonism, therefore hyperfrontalities were well preserved in all of the patients. Acute intravenous administration of L-DOPA gave rise to a diffuse increase in 1-CBF only in the patients and the increment was more prominent in patients severely affected than in those mildly affected. It was concluded that reduction of 1-CBF in the basal ganglia and cortex may be attributed to hypometabolism in the mesostriatal and mesocortical dopaminergic system.}
journal = {Keio Igaku; (Japan)}
volume = {64:4}
journal type = {AC}
place = {Japan}
year = {1987}
month = {Jul}
}